Esomeprazole Magnesium Trihydrate 40 mg Tablet

Adult dosage

Swallow this medicine with a liquid such as water; do not chew or crush it. Adults Gastroesophageal reflux disease (GERD) Treatment of erosive reflux esophagitis: Administer 40 mg once daily for 4 weeks. Patients whose esophagitis has not healed or whose symptoms persist should take it for an additional 4 weeks. Long-term maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily Symptomatic treatment of gastroesophageal reflux disease without esophagitis: 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is required. Once symptoms have resolved, subsequent symptoms may be controlled by administering 20 mg once daily. In adults, 20 mg may be administered once daily as needed. As-needed administration to control subsequent symptoms is not recommended for patients at high risk of developing gastric and duodenal ulcers due to use of nonsteroidal anti-inflammatory drugs. Combination therapy with antibiotics for eradication of Helicobacter pylori Administer this medicine 20 mg with amoxicillin 1 g and clarithromycin 500 mg twice daily for 7 days. Short-term treatment of upper gastrointestinal symptoms (pain, discomfort, burning) associated with use of nonsteroidal anti-inflammatory drugs (nonselective or selective COX-2 inhibitors) 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is required. Clinical trials lasting longer than 4 weeks have not been conducted. Patients requiring ongoing nonsteroidal anti-inflammatory drug therapy Treatment of gastric ulcers associated with nonsteroidal anti-inflammatory drug use: 20 mg once daily. The treatment period is 4∼8 weeks. Prevention of gastric and duodenal ulcers associated with nonsteroidal anti-inflammatory drug use: 20 mg once daily. Treatment of Zollinger-Ellison syndrome The recommended initial dose is 40 mg twice daily. The dose should subsequently be adjusted for each patient, and treatment should continue for as long as clinical symptoms are present. Clinical data indicate that most patients can be controlled with doses of 80 ∼ 160 mg daily. Doses above 80 mg daily should be divided into two doses. Maintenance therapy following intravenous treatment to prevent rebleeding from gastric or duodenal ulcers Administer 40 mg once daily for 4 weeks following intravenous treatment to prevent rebleeding from gastric or duodenal ulcers. Renal impairment: No dose adjustment is necessary. Use with caution because there is limited experience in patients with severe renal failure. Hepatic impairment: No dose adjustment is necessary in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, do not exceed a dose of 20 mg of this medicine. Older adults: No dose adjustment is necessary.

Children's dosage

Adolescents aged 12 years and older — Gastroesophageal reflux disease (GERD), treatment of erosive reflux esophagitis: Administer 40 mg once daily for 4 weeks. Patients whose esophagitis has not healed or whose symptoms persist should take it for an additional 4 weeks. Adolescents aged 12 years and older — Symptomatic treatment of gastroesophageal reflux disease without esophagitis: 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is required. Adolescents aged 12 years and older — Symptomatic treatment of gastroesophageal reflux disease without esophagitis: Once symptoms have resolved, subsequent symptoms may be controlled by administering 20 mg once daily. Children under 12 years: There is no experience with administration of this medicine to children under 12 years of age.

This medication should not be administered to certain patients. For instance, it should not be used in cases of allergy to this medication or its components, or in cases of hypersensitivity to certain antibiotics or drugs. Additionally, individuals with a history of heart disease or nursing women should avoid taking this medication. Caution is required because various side effects may occur when taking this medication. Common symptoms include headaches, dizziness, dyspepsia, skin rash, while rare but severe reactions may include serious blood abnormalities or liver function impairment, and severe allergic reactions. Long-term use of this medication requires regular health check-ups, especially when used for more than one year, with periodic monitoring of magnesium levels or liver function. This medication can interact with other drugs, so if you are taking other medications, be sure to inform your doctor or pharmacist. Care should be taken especially when used in combination with drugs affecting blood clotting, antiviral drugs, and antibiotics. This medication should be used cautiously during pregnancy, and it is advisable to avoid its use while breastfeeding. In cases of overdose, as there is no specific antidote, urgent medical attention should be sought. Finally, this medication should be stored out of reach of children, and it's safest not to transfer it to another container.

Leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, fever, angioedema, anaphylactic reaction, shock, peripheral edema, hyponatremia, hypomagnesemia, insomnia, anxiety, confusion, depression, aggression, hallucinations, headache, dizziness, paresthesia, drowsiness, taste disorder, blurred vision, bronchospasm, pancreatitis, abdominal pain, constipation, diarrhea, abdominal distension, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, microscopic colitis, elevated liver enzymes, hepatitis, liver failure, encephalopathy, dermatitis, itching, rash, urticaria, hair loss, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms, fractures, arthralgia, myalgia, muscle weakness, interstitial nephritis, gynecomastia, asthenia, increased sweating, Clostridium difficile-associated diarrhea, abdominal bloating, allergic reaction, back pain, chest pain, substernal pain, facial swelling, facial flushing, fatigue, fever, influenza-like illness, generalized edema, leg swelling, malaise, pain, rigidity, peripheral edema, flushing, hypertension, tachycardia, thyroid goiter, irritable bowel syndrome, worsening of constipation, dyspepsia, dysphagia, gastrointestinal malformation, upper abdominal pain, belching, esophageal disorders, frequent bowel movements, gastroenteritis, gastrointestinal bleeding, hiccups, melena, oral disorders, pharyngeal disorders, rectal disorders, gastrointestinal symptoms, increased serum gastrin, tongue disorders, tongue swelling, ulcerative stomatitis, vomiting, ear pain, tinnitus, anemia, hypochromic anemia, cervical lymphadenopathy, epistaxis, leukocytosis, leukopenia, thrombocytopenia, hyperbilirubinemia, abnormal liver function, elevated ALT, elevated AST, diabetes, hyperuricemia, elevated ALP, polydipsia, vitamin B12 deficiency, weight gain, weight loss, exacerbation of arthritis, arthropathy, convulsions, fibromyalgia syndrome, hernia, rheumatoid polymyalgia, arthralgia, loss of appetite, apathy, increased appetite, confusion, worsening depression, hypertonia, anxiety, sensory deficit, erectile dysfunction, insomnia, migraine, worsening of migraine, sleep disorders, tremors, dizziness, visual field defects, paresthesia, drowsiness, dysmenorrhea, menstrual disorders, vaginitis, exacerbation of asthma, cough, dyspnea, laryngeal edema, pharyngitis, rhinitis, sinusitis, acne, anal itching, rash, erythematous rash, papular rash, angioedema, dermatitis, itching, urticaria, increased sweating, otitis media, dysosmia, taste loss, parageusia, urinary abnormalities, albuminuria, cystitis, dysuria, fungal infection, hematuria, urinary frequency, candidiasis, genital candidiasis, polyuria, conjunctivitis, visual disturbances, duodenitis, esophagitis, esophageal stricture, esophageal ulcer, esophageal varices, gastric ulcer, gastritis, benign polyps or nodules, Barrett's esophagus, mucosal discoloration, hernia, systemic lupus erythematosus, cutaneous lupus erythematosus, gastric mucosal polyp, hypocalcemia, hypokalemia, rhabdomyolysis, myalgia, elevated creatine kinase, increased serum and urinary myoglobin

This medication should be stored in a tightly closed container to prevent air and moisture from entering, at room temperature between 1°C and 30°C. This way of storage helps to maintain the efficacy of the medication safely.

Appearance

Pink round film-coated tablet

Package unit

28 tablets (14 tablets x 2 PTP)