Hironaplus Injection (Pre-filled) (Sodium Hyaluronate)

Adult administration

Typically, for adults, 1 syringe is administered into the knee joint or shoulder joint once a week for 3 consecutive weeks. The frequency of administration should be adjusted appropriately depending on symptoms.

This medication contains sodium hyaluronate and is injected into the joint. First, it should never be used in patients who have had allergic reactions to any of its components. Also, patients who have had allergic reactions to other medications or those with liver function issues or a history of liver disease should use it with caution. Care should be taken if there is a skin disease or infection at the injection site. Rarely, severe shock symptoms may occur after administration, so the condition should be closely monitored, and if any abnormal symptoms appear, use should be immediately stopped and appropriate treatment sought. Additionally, allergic symptoms such as swelling of the face or around the eyes, rashes, or itching may appear, and if these symptoms occur, the medication should be discontinued. Temporary pain, swelling, redness, warmth, and pressure may occur at the injected joint, so this should also be noted. Nausea, vomiting, and fever may appear occasionally, so any abnormal symptoms should be reported. For joints with severe inflammation, it is best to reduce inflammation first before using this medication. After administration, stabilizing the injection site is helpful, and care should be taken to prevent the medication from leaking out of the joint. Injections must be performed in a sterile environment, and if symptoms do not improve, it should be injected only up to 3 times and then discontinued. If there is an excess of joint fluid, it may be drained before administration for safety. It should not be administered intravenously or used for ophthalmic purposes, and 22-23 gauge needles are recommended for injection. This medication may form precipitates if used with sterilizing agents, so caution is advised. For women who are pregnant or may become pregnant, its safety has not been established, so it should only be used with caution when the benefits of treatment outweigh the risks. Additionally, during breastfeeding, since this medication may be transmitted through breast milk, it is recommended to avoid breastfeeding while using this medication. Its safety has not been established for children, so it should only be used with caution when absolutely necessary. Elderly patients may have decreased physical function, so caution is needed during use.

Serious side effects

• Hives
• swelling (facial, eyelid, etc.)
• shock symptoms

Mild side effects

• Facial flushing
• itching
• pain
• swelling
• redness
• warmth
• severe localized pressure
• nausea
• vomiting
• fever

This medication should be stored in a sealed container at room temperature between 1 and 30 degrees Celsius. This will help maintain the effectiveness of the medication and prevent degradation.

Appearance

A colorless, transparent, and viscous liquid contained in a glass or plastic tube (pre-filled syringe) sealed with rubber stoppers at both ends.

Package unit

2.0 mL (1 syringe) × 3