Roxferin Tablets (Loxoprofen Sodium Hydrate)

Adult dose

1. For indications 1 and 2: Adults: Administer 60 mg of loxoprofen sodium (anhydrous) orally three times a day. In case of single-dose therapy, take 60 to 120 mg orally. 2. For indication 3: Adults: Administer 60 mg of loxoprofen sodium (anhydrous) orally. In principle, it can be administered up to twice a day and a maximum of 180 mg per day. It is advisable to avoid taking it on an empty stomach.

This medication should be taken with caution in individuals who regularly consume more than three alcoholic beverages daily, as it may pose a risk of gastrointestinal bleeding; consultation with a physician or pharmacist is essential. Containing non-steroidal anti-inflammatory drug (NSAID) components, it may increase the risk of cardiovascular diseases, leading to serious cardiovascular issues such as myocardial infarction or stroke. Furthermore, this medication can cause serious gastrointestinal problems such as gastrointestinal bleeding, ulcers, or perforation; thus, those with a history of gastrointestinal diseases or the elderly should be especially careful. Patients with peptic ulcers, severe liver impairment, kidney impairment, heart failure, and those allergic to this medication or its components should not take it. Patients with a history of asthma or hypersensitivity to aspirin should also refrain from using this medication, as should pregnant women in late pregnancy and nursing mothers. Patients with a history of peptic ulcers or issues with kidney or liver function, as well as those with hypertension, heart failure, or bleeding disorders, should use this medication cautiously. If symptoms of hypersensitivity such as rash, itching, or difficulty breathing occur during use, the medication should be stopped immediately, and medical attention should be sought. Gastrointestinal symptoms may include abdominal pain, nausea, vomiting, bloody stools, and immediate consultation with a physician is necessary if such symptoms occur. Neurological symptoms such as drowsiness, dizziness, and headache have also been reported; caution is advised when driving or operating machinery. Abnormal liver function, decreased kidney function, and hematological symptoms may also occur, which necessitate regular checks during prolonged use. This medication should not be taken in conjunction with other NSAIDs due to an increased risk of side effects. Additionally, interactions may occur with some antihypertensives, diuretics, anticoagulants, lithium, and methotrexate, so caution is required when taken together. It should not be used, particularly during late pregnancy, and in early or middle pregnancy, it should only be used at the minimum effective dose for a short duration when absolutely necessary. It is safest not to use this medication during breastfeeding. Safety for children has not been established, and the elderly are at greater risk of side effects, thus they should be more cautious. Store out of reach of children and avoid transferring to a different container.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with high fever, blisters, skin peeling, pain in oral/eye mucosa, severe skin adverse reactions, difficulty breathing or breathlessness, asthma attacks, respiratory problems with cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, liver disorders (jaundice), sudden

Mild side effects

• Occasionally rash
• itching
• fever
• abdominal pain
• gastric discomfort
• loss of appetite
• nausea
• vomiting
• diarrhea
• constipation

This medication may be sensitive to air and moisture, therefore, it should be stored in a tightly sealed container. Additionally, avoid extremely hot or cold environments, and it is best to store it at room temperature between 1°C and 30°C.

Appearance

White to pale yellow round tablets

Package unit

30 tablets/bottle, 300 tablets/bottle