Ranigen Tablet

Adult dose

Typically administered orally at a dose of 2 tablets twice a day before breakfast and at bedtime, regardless of meals. 1) Gastric and duodenal ulcers Administer 2 tablets twice daily or 4 tablets once daily at bedtime. Especially for patients with duodenal ulcers, administering 4 tablets twice a day before breakfast and at bedtime can achieve a higher treatment rate. Administration regimen is the same for preventing ulcers due to the use of non-steroidal anti-inflammatory drugs or associated with long-term use of non-steroidal anti-inflammatory drugs. Typically, conditions resulting from NSAID administration heal within 8 weeks, though healing time may be prolonged depending on the patient. For patients with recurrent ulcers who have shown excellent effects from short-term therapy with this medication, maintenance therapy with 2 tablets once daily at bedtime is recommended. 2) Gastroesophageal reflux disease Administer 2 tablets twice daily for 8 weeks or 4 tablets once daily at bedtime. For patients with severe gastroesophageal reflux disease, the dosage may be increased to 4 tablets four times a day. 3) Zollinger-Ellison syndrome Start treatment with an initial dose of 2 tablets three times a day and may increase as needed. In severe cases, a physician may prescribe up to 6 g per day of ranitidine. 4) Peptic ulcers, acute stress-induced ulcers, and upper gastrointestinal bleeding due to acute mucosal lesions Switch to oral administration with 2 tablets twice a day once oral intake is possible after intravenous administration. 5) Pre-anesthetic administration (prevention of Mendelson's syndrome) Administer 2 tablets 2 hours prior to induction of anesthesia. It is also beneficial to administer 2 tablets on the night before surgery.

This drug should not be used in patients undergoing dialysis or those with kidney function issues. In addition, individuals who have shown allergic reactions to this drug or its components should avoid taking it. Patients with a rare condition called acute porphyria should also be cautious, as symptoms may worsen with this medication. It is not recommended for patients who have undergone upper gastrointestinal surgery, pregnant women or those who could become pregnant, preterm infants and newborns, as well as patients who need to restrict potassium intake. Patients with liver function issues, those with a history of drug allergies, the elderly, and those with a history of renal impairment should use this medication cautiously. In cases where non-steroidal anti-inflammatory drugs are being used, particularly elderly patients or those with a history of peptic ulcers, regular monitoring of their condition is necessary. This medication can mask symptoms of gastric cancer, so patients with gastric ulcers or those who recently developed or had changes in dyspeptic symptoms, especially those over middle age, should confirm whether it is not a malignant condition before treatment. Patients with Helicobacter pylori infection and gastric or duodenal ulcers require eradication treatment. Caution is also needed for critically ill patients, those with hypophosphatemia, and patients with swallowing difficulties when using this drug. This medication rarely can cause serious allergic reactions or shock, so if any abnormal symptoms appear during administration, it should be stopped immediately, and medical personnel should be consulted. Allergic reactions such as skin rash, hives, angioedema, fever, bronchospasm may also occur, and these should prompt discontinuation of the medication. Blood-related side effects such as leukopenia, thrombocytopenia, and liver dysfunction may be reported, and if symptoms occur, immediate reporting to medical personnel is necessary. Gastrointestinal symptoms may include nausea, vomiting, constipation, diarrhea, abdominal pain, and changes in stool color may occur, but these do not require special treatment. CNS-related symptoms may include dizziness, drowsiness, confusion, seizures, insomnia, and headaches, especially in patients with poor kidney function. Rarely, side effects such as gynecomastia, erectile dysfunction, myalgia, skin rash, and hair loss may occur. Long-term use should be avoided, and if there is no therapeutic effect, other medications should be considered. The elderly or immunocompromised patients may be at increased risk for pneumonia, so caution is advised. If experiencing dizziness or drowsiness, avoid driving or operating dangerous machinery. This medication may interact with other drugs, so inform your healthcare provider if you are currently taking other medications. It is safe to avoid using this medication for women who are pregnant or breastfeeding. Safety in pediatric patients has not been established, so it is advisable not to use it. In cases of overdose, emergency treatment such as vomiting or gastric lavage may be needed, and blood dialysis may help in certain cases.

Serious side effects

Hives, angioedema, anaphylactic shock, chest pain, hypotension, skin rash, severe swelling (including angioedema), chest tightness, difficulty breathing, bronchospasm, severe rash with fever, blisters, skin shedding, pain in mouth/eye mucosa, liver dysfunction (including jaundice), severe swelling, significant swelling or urinary abnormalities, systemic malaise, weakness, subcutaneous/mucosal bleeding, fever, reversible jaundiced hepatitis, non-jaundiced

Mild side effects

• Skin rash
• hives
• angioedema
• fever
• bronchospasm
• hypotension
• chest pain
• nausea
• vomiting
• constipation

Store this medication in a tightly sealed container to prevent air from entering, and it is best kept at room temperature between 1 and 30 degrees Celsius. By following these storage instructions, the effectiveness of the medication can be preserved for a longer duration.

Appearance

Round white film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle