Nizicid Capsule 150mg (Nizatidine)

Adult dose

Treatment of active gastric and duodenal ulcers Adults: Administer 300mg of nizatidine once daily at bedtime, or 150mg orally twice daily, in the morning and evening. Most ulcers heal within 4 weeks, but treatment may be continued for up to 8 weeks if necessary. Prevention of recurrence of duodenal ulcers Adults: After healing of a duodenal ulcer, administer 150mg orally once daily at bedtime. Treatment may be continued for up to 1 year; results for longer-term use are not known. Gastroesophageal reflux disease Adults: Administer 150mg orally twice daily, in the morning and evening. Treatment may be continued for up to 12 weeks. Improvement of gastric mucosal lesions Adults: Administer 150mg orally twice daily, in the morning and evening, for 2 weeks. Dosage adjustment for patients with severe renal impairment The dose for patients with renal impairment should be reduced and adjusted as follows. Active duodenal ulcer, gastroesophageal reflux disease (GERD), benign gastric ulcer — creatinine clearance 20~50 ml/min: 150mg per day Active duodenal ulcer, gastroesophageal reflux disease (GERD), benign gastric ulcer — creatinine clearance < 20 ml/min: 150mg every other day Maintenance therapy — creatinine clearance 20~50 ml/min: 150mg every other day Maintenance therapy — creatinine clearance < 20 ml/min: 150mg every 3 days Some elderly patients may have a creatinine clearance below 50mL/min; based on pharmacokinetic data in patients with renal impairment, the dose should also be reduced in these patients according to the degree of renal impairment.

This medication should not be used in certain patients. Particularly, patients who are allergic to this drug or similar drugs or have genetic issues such as lactose intolerance should not take it. Additionally, patients with hypersensitivity to the medication or issues with liver or kidney function should exercise caution when using this drug. For patients with reduced kidney function, the dose should be reduced or dosing intervals increased. Rarely, allergic reactions such as skin rashes, itching, and respiratory distress may occur; if these symptoms develop, the medication should be discontinued immediately. Various side effects such as anemia, changes in white blood cell count, digestive disorders, liver function abnormalities, mental confusion, headaches, dizziness, arrhythmias, gynecomastia in women, skin rashes, and others have been reported and require caution. This medication can mask symptoms of gastric cancer; therefore, it should only be used when it is certain that it is not gastric cancer, and dose adjustment is necessary for patients with impaired kidney function. Pregnant or breastfeeding women should carefully consider the potential effects on the fetus and baby when using this medication. Older adults are at higher risk of decreased kidney function, so it is advisable to conduct kidney function tests first and closely monitor kidney status during use. This drug has a relatively low potential for interactions with other drugs, but taking it with high doses of aspirin may increase serum salicylate concentration. In case of overdose, symptoms such as vomiting or diarrhea may occur, necessitating appropriate treatment and supportive therapy. This drug cannot be effectively removed by hemodialysis. Although long-term high-dose administration is not known to significantly increase the risk of cancer, caution is still advised as it can affect liver function. Some test results may be affected during clinical testing, so it is important to inform the testing facility that this medication has been taken.

• Rash
• itching
• bronchial asthma
• laryngeal edema
• symptoms of anaphylaxis
• anemia
• leukopenia
• neutrophilia
• thrombocytopenic purpura
• constipation

This medication should be stored in a tightly sealed container to prevent air exposure and should be kept at room temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the effectiveness of the medication.

Appearance

A hard capsule with a yellow upper part and a light yellow lower part containing a whitish powder.

Package unit

30 capsules/bottle, 300 capsules/bottle