Nizatidine Capsule 150 mg (Nizatidine)

Adult dose

1. Treatment of active gastric or duodenal ulcers Adults: Administer 300mg of nizatidine once daily at bedtime, or 150mg orally twice daily, in the morning and evening. Most ulcers heal within 4 weeks, but treatment may be continued for up to 8 weeks if necessary. In cases of active gastric ulcer, malignancy must be ruled out before treatment. 2. Prevention of recurrence of duodenal ulcers Adults: After healing of a duodenal ulcer, administer 150mg orally once daily at bedtime. Treatment may be continued for up to 1 year; outcomes with longer-term treatment are not known. 3. Gastroesophageal reflux disease Adults: Administer 150mg orally twice daily, in the morning and evening. Treatment may be continued for up to 12 weeks. 4. Improvement of gastric mucosal lesions Adults: Administer 150mg orally twice daily, in the morning and evening, for 2 weeks. 5. Dosage adjustment for patients with severe renal impairment The dose should be reduced and adjusted as follows for patients with renal impairment. Creatinine clearance Dosage Active duodenal ulcer Gastroesophageal reflux disease (GERD) Benign gastric ulcer 20~50 ml/min 150mg daily < 20 ml/min 150mg every other day Maintenance therapy 20~50 ml/min 150mg every other day < 20 ml/min 150mg every 3 days Some elderly patients may have a creatinine clearance below 50mL/min. Based on pharmacokinetic data in patients with renal impairment, the dose should also be reduced in these patients according to the degree of renal impairment. The clinical impact of this dose reduction in patients with renal impairment has not been evaluated.

This drug should not be used in patients with known allergic reactions or histories of hypersensitivity to specific medications. Care should be taken when using this drug in patients with liver or kidney function problems. Especially in cases of impaired kidney function, the blood concentration of the drug may increase, so the dosage should be reduced or the dosing interval prolonged. This medication contains a dye called Yellow No. 5, so caution is advised for patients allergic to this ingredient. During use, allergic symptoms such as skin rash, itching, and difficulty in breathing may occur; if these symptoms appear, discontinue use immediately. Adverse effects such as anemia or abnormalities in blood cell counts, digestive disturbances, liver function abnormalities, confusion, headache, dizziness, weakness, ventricular tachycardia, gynecomastia, erectile dysfunction, decreased libido, sweating, exfoliative dermatitis, vasculitis, hyperuricemia, fever, chest pain, myalgia, rhinitis, pharyngitis, coughing may occur; consult a physician if unusual symptoms arise. Also, this drug can mask symptoms of stomach cancer, so it should only be used after confirming it is not a malignant condition. Patients with reduced kidney function or the elderly should determine the appropriate dosage through kidney function tests, and the kidney condition should be closely monitored during treatment. Women who are pregnant or breastfeeding should only use this drug if the benefits of treatment outweigh the risks, as its safety has not been established. Safety in children has not been sufficiently confirmed, so it should be administered cautiously to children. In case of overdose, symptoms such as vomiting or diarrhea may appear, and appropriate treatment should be sought if necessary. This drug generally has few interactions with other medications, but caution is needed when used with high-dose aspirin. Finally, it is important to have regular blood tests and liver and kidney function tests to check for abnormalities during the use of this medication.

• Rash
• pruritus
• bronchial asthma
• laryngeal edema
• anaphylaxis symptoms
• anemia
• leukopenia
• neutrophilia
• thrombocytopenic purpura
• constipation

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is best kept at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain its effectiveness for a long time.

Appearance

A hard capsule with a purple upper part and a pale yellow lower part filled with a white to gray-white powder

Package unit

30 capsules/bottle, 300 capsules/bottle