Eston (Lafutidine)

Adult dose

1. Short-term treatment of gastric ulcers: The usual dose is 10mg of lafutidine per dose, administered orally twice daily, in the morning and at bedtime. Clinical trial results for treatment for up to 8 weeks showed that most ulcers healed within 8 weeks, although the healing period may occasionally vary among patients. 2. Short-term treatment of duodenal ulcers: The usual dose is 10mg of lafutidine per dose, administered orally twice daily, in the morning and at bedtime. Clinical trial results for treatment for up to 6 weeks showed that most ulcers healed within 6 weeks, although the healing period may occasionally vary among patients. 3. Improvement of gastric mucosal lesions in acute and chronic gastritis: The usual dose is 10mg of lafutidine orally once daily at bedtime. Clinical trial results for treatment for up to 2 weeks showed that most lesions healed within 2 weeks, although the healing period may occasionally vary among patients. 4. Concomitant antibiotic therapy in patients with peptic ulcers infected with Helicobacter pylori: Administer lafutidine 20mg, clarithromycin 500mg, and amoxicillin 1000mg twice daily for 7 or 14 days. 5. Premedication before anesthesia: The usual dose is 10mg of lafutidine per dose, administered orally twice (at bedtime on the day before surgery and 2 hours before anesthesia on the day of surgery). 6. Treatment of reflux esophagitis: Administer lafutidine 10mg per dose orally twice daily.

This medication should not be used in patients who are allergic to any of its components. It contains lactose, so patients with genetic conditions such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should not take it. It should be administered with caution to patients with a history of drug allergies, liver or kidney impairment, those undergoing dialysis, and elderly individuals as their physiological functions may be diminished. While taking this medication, patients should be vigilant for symptoms of severe allergic reactions such as anaphylaxis, liver dysfunction, or blood cell count reduction; should any unusual symptoms occur, usage should be immediately discontinued and appropriate medical treatment sought. Gastrointestinal symptoms may include constipation, diarrhea, nausea, vomiting, abdominal bloating, and loss of appetite, while central nervous system symptoms can manifest as headache, insomnia, drowsiness, dizziness, and malaise. Various side effects such as blood cell abnormalities, elevated liver enzyme levels, kidney dysfunction, skin rash, edema, and fatigue have been reported, thus requiring caution. In particular, if malignant tumors such as gastric cancer are suspected, this medication may alleviate symptoms, potentially delaying diagnosis; thorough examinations should be conducted if any suspicious symptoms arise. Elderly individuals should have their dosage and administration intervals adjusted as their bodily functions are compromised and should be closely monitored for any adverse effects. Patients undergoing dialysis may experience elevated blood drug concentrations, so administration should begin at low doses with careful attention. Pregnant women or those with childbearing potential should only take this medication if the benefits outweigh the risks under a physician's assessment, and nursing mothers are advised not to take it as it may be excreted in breast milk. Safety in children has not been sufficiently established, so it is preferable not to use it in pediatric patients. Lastly, this medication should be stored out of reach of children and kept in its original container to prevent misuse or degradation of quality.

• Shock
• anaphylactic symptoms
• pallor
• hypotension
• generalized rash
• dyspnea
• liver function impairment
• jaundice
• agranulocytosis
• pharyngitis

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best kept at room temperature between 1°C and 30°C.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle