Megavitamin B6 Injection (Pyridoxine Hydrochloride)

Adult dosage

As pyridoxine hydrochloride, administer 10-100 mg daily divided into 1 to 2 doses via intramuscular, subcutaneous, or intravenous injection. In cases of vitamin B6 dependency, higher doses may be administered. Adjust according to age and symptoms.

This medication is an ampoule injection, and great care must be taken when cutting the container to avoid the ingress of glass shards which could cause adverse reactions. Extra caution is necessary when administering to children and the elderly. It should not be administered to patients with hypersensitivity to any of the components or those taking levodopa. Symptoms such as photosensitivity reactions, nausea, headache, and drowsiness may occur, so careful observation of symptoms is required. Long-term high-dose administration may cause neurological disturbances such as seizures, limb paralysis, and ataxia, and recovery may take a long time even after discontinuation. Injection may cause discomfort or pain at the injection site. In cases of large doses administered to newborns or infants, severe side effects such as muscle damage and kidney injury may occur, and the condition must be closely monitored, stopping administration immediately if any abnormal signs occur. High-dose administration during pregnancy may be associated with vitamin B6 dependency syndrome in newborns and infants, so caution is advised. Particularly when administering to newborns and infants, it should begin with small doses and be gradually increased according to the symptoms. After high-dose administration, temporary dependency may arise, warranting a gradual reduction method for discontinuation. This medication can reduce the effectiveness of levodopa when co-administered, so they should not be used together. Additionally, isoniazid, penicillamine, and estrogen preparations may increase the need for vitamin B6, necessitating caution. In patients with ovarian cancer, co-administration of altretamine and cisplatin may reduce neurotoxicity but can decrease therapeutic effectiveness, so they should not be used together. Keep out of reach of children, store in a cool, dry place away from direct sunlight. Storing the medication in a different container from the original may cause misuse or degradation of quality, so it must be stored in the original container and tightly closed.

Serious side effects

• Seizures
• peripheral paralysis
• sensory neuropathy accompanied by ataxia
• rhabdomyolysis
• acute renal failure

Mild side effects

• Photosensitivity reactions
• nausea
• headache
• drowsiness
• discomfort during injection
• pain
• diarrhea
• vomiting
• abnormal liver function

This medication is sensitive to light and should be stored in a container that does not allow light to pass through. Furthermore, to maintain the medication's effectiveness, it is important to store it at room temperature, specifically between 1°C and 30°C.

Appearance

A brown ampoule containing a colorless to light yellow liquid for injection

Package unit

1mL/ampoule X 50