Withus Risedronate Sodium 35 mg

Adult dose

1. Adults: Administer one 35mg tablet orally once weekly. 2. Older adults: No dosage adjustment is necessary because the bioavailability and pharmacokinetics of this medicine in older adults (60 years of age and older) are similar to those in younger adults. 4. Patients with renal impairment: No dosage adjustment is necessary in patients with a creatinine clearance of 30ml/min or greater. This medicine is contraindicated in patients with severe renal impairment and a creatinine clearance below 30ml/min. Because food interferes with the absorption of this medicine, take it as follows to ensure adequate absorption. Take it at least 30 minutes before breakfast, or at least 2 hours before or after consuming food or beverages at any time of day. To help the medicine reach the stomach readily and reduce the possibility of esophageal irritation, take it in an upright position with a sufficient amount of plain water (170 ~ 230ml). Taking this medicine with other beverages, including mineral water, may reduce its absorption. Do not chew or suck the tablet because of the possibility of oropharyngeal ulceration. Patients should not lie down for at least 30 minutes after taking it. If a patient forgets to take the medicine on the scheduled day, take it the next morning when remembered. Resume taking it on the originally scheduled day for the next dose. Do not take 2 tablets on the same day.

Child dose

3. Children: The safety and efficacy of this medicine in children and adolescents who are still growing have not been established.

This drug may irritate the gastrointestinal mucosa, so individuals with diseases of the esophagus or stomach should consult a physician before use. Particularly, conditions such as esophagitis, esophageal ulcers, and esophageal inflammation can be serious, so if symptoms such as difficulty swallowing or chest pain occur, discontinue use immediately and inform a healthcare professional. When taking this medication, it should be taken while sitting or standing with plenty of water, and one should not lie down for at least 30 minutes after taking it. This drug is contraindicated for individuals with certain esophageal diseases, hypocalcemia, severe renal impairment, or for women who are pregnant or breastfeeding. Individuals with genetic disorders that prevent lactose digestion should also avoid this medication. Those with upper gastrointestinal disorders such as Barrett's esophagus, gastritis, or duodenitis should use with caution, and individuals with allergies to the coloring agents in the medication should be careful. Common side effects include dyspepsia, abdominal pain, diarrhea, headache, joint pain, and muscle pain, while rare but serious skin reactions or esophageal damage have been reported. Long-term use may also lead to rare side effects such as atypical femoral fractures or osteonecrosis of the jaw, so one should consult a healthcare professional immediately if any unusual symptoms arise. Taking this medication simultaneously with other drugs or foods containing minerals such as calcium, magnesium, or iron may interfere with its absorption, so dosage intervals should be maintained. If pregnant or breastfeeding, alternatives should be sought or medical advice should be obtained; safety in children under 18 has not been established. In cases of overdose, symptoms of hypocalcemia may appear, and one should visit a healthcare institution immediately. Store in a safe place out of reach of children.

• Esophagitis
• esophageal ulcer
• esophageal erosion
• esophageal obstruction
• esophageal perforation
• bleeding
• gastric ulcer
• duodenal ulcer
• dyspepsia
• diarrhea

This medication should be stored in a sealed container to prevent air ingress and kept at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication.

Appearance

Pale orange oval film-coated tablet

Package unit

4 tablets/PTP