Rabeprazole Sodium 10 mg Tablets

Adult dose

For gastric ulcers and duodenal ulcers: the usual adult dosage is 10 mg of rabeprazole sodium orally once daily. Depending on the symptoms, it may be increased to 20 mg orally once daily. Generally, treatment for gastric ulcers lasts up to 8 weeks, and for duodenal ulcers up to 6 weeks. For erosive or ulcerative gastroesophageal reflux disease: 10 mg or 20 mg may be administered orally once daily for 4 to 8 weeks. If proton pump inhibitors (PPI) are used for 8 weeks with no improvement, an additional 8 weeks of 10 mg or 20 mg may be administered twice daily orally. However, the 20 mg twice daily regimen is only for patients with confirmed severe mucosal damage. For symptom relief of gastroesophageal reflux disease: 10 mg should be taken once daily. If symptoms are not controlled after 4 weeks, further medical consultation is necessary. Once symptoms have resolved, as-needed therapy with 10 mg once daily can be used to manage subsequent symptoms. For long-term maintenance therapy of gastroesophageal reflux disease: patients may take 10 mg or 20 mg orally daily, depending on individual needs. For Helicobacter pylori eradication: patients infected with Helicobacter pylori should undergo eradication therapy, which is recommended to include a combination of this medication 20 mg, clarithromycin 500 mg, and amoxicillin 1 g, administered twice daily for 7 days. For Zollinger-Ellison syndrome: the recommended initial dose for adults is 60 mg orally once daily, and the dose may be adjusted up to 120 mg daily based on individual patient needs. Doses up to 100 mg may be given once daily, while 120 mg should be split into two doses of 60 mg each. Patients with Zollinger-Ellison syndrome have been treated with this medication for up to 1 year. Hepatic impairment: Adverse reactions of hepatic encephalopathy have been reported in cirrhotic patients; therefore, caution is warranted. Pediatrics: Safety in pediatric patients has not been established. Geriatrics: Caution is warranted due to the common occurrence of reduced liver function.

This medication should not be used in patients with specific allergic reactions or hypersensitivity to its components. Additionally, it should not be administered to women who are pregnant or breastfeeding. Caution is required when using this medication in patients with poor liver function or elderly patients, and special caution is needed in those with a history of hypersensitivity to the medication. If any allergic symptoms such as skin rash or itching occur during treatment, the medication must be discontinued immediately. Routine blood tests are recommended as there may be changes in red or white blood cell counts. Liver function tests should also be conducted regularly, and if abnormalities are detected, the medication should be discontinued immediately. Cardiovascular symptoms or blood pressure changes, headaches, or dizziness may occur, and if these symptoms appear, medical consultation is necessary. Gastrointestinal symptoms such as diarrhea, constipation, abdominal pain, or nausea may occur, so caution is advised. Neurological symptoms may include headaches, insomnia, anxiety, or dizziness, and in severe cases, professional consultation may be required. Respiratory symptoms, muscle aches, joint pain, skin rashes, vision changes have also been reported, so any unusual symptoms should be reported. Prolonged use of this medication may increase the risk of bone fractures, so caution is necessary for long-term use. Additionally, magnesium levels may decrease, warranting regular blood tests and potential magnesium supplementation. This medication may interact with some other medications, especially when taken with antibiotics, anticoagulants, or antivirals, so consultation with a healthcare professional is essential. Taking it with food generally poses no significant problems, but be aware that high-fat meals may delay drug absorption. Caution is required when driving or operating machinery as drowsiness or decreased alertness may occur. This medication should be swallowed whole without chewing or crushing, and stored out of reach of children. Regular check-ups and consultations with healthcare professionals are necessary to ensure safe long-term use.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, jaundice, liver dysfunction, acute interstitial nephritis, severe allergic reactions, fulminant hepatitis, hepatitis, hepatic encephalopathy, toxic epidermal necrolysis (Lyell syndrome), Stevens-Johnson syndrome, deep vein thrombosis, shock, anaphylaxis, angioedema, thunderclap headache, seizures, confusion, visual disturbances, paralysis, severe edema associated with increased blood pressure, sudden death

Mild side effects

• Rash
• itching
• decreased red blood cells
• decreased white blood cells
• increased white blood cells
• increased eosinophils
• increased neutrophils
• decreased lymphocytes
• anemia
• petechiae

This medication may be sensitive to air and moisture, so it must be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature. This will help preserve its efficacy and safety for a long period.

Appearance

Pale yellow round enteric-coated tablet

Package unit

28 tablets (14 tablets/PTP*2), 28 tablets (28 tablets/PTP*1)