Disterin Capsule (Diacerein)

Adult dose

Adults: Administer 50∼100mg of diacerein orally after meals in 1∼2 divided doses daily. Adjust the dose as appropriate according to symptoms. For patients with a history of loose stools or diarrhea, an initial dose of 50mg once daily for the first 2-4 weeks is recommended, followed by 50mg twice daily.

This medication should not be used in certain patients. For example, patients with inflammatory bowel disease or bowel obstruction syndrome, those experiencing unexplained abdominal pain, and individuals who are allergic to this medication or its components should avoid it. Additionally, it is safer not to take this medication for patients with liver disease or prior liver problems, children under 15 years of age, and those with genetic issues digesting lactose. There are also cases where caution should be taken. Patients with a history of small intestine or colon disease should use this medication carefully, and women who are pregnant or breastfeeding, as well as the elderly over 65 years, should reduce the dosage or take caution while using it. This medication contains a dye called Yellow No. 5, which requires caution in individuals allergic to this component. Various side effects may occur during use. In the digestive system, diarrhea, loose stools, and abdominal pain may commonly occur, and prolonged use can lead to serious issues such as gastrointestinal bleeding, ulcers, and perforations. Severe diarrhea may result in dehydration and electrolyte imbalance, necessitating caution. Skin symptoms may include itching, rash, and eczema, and it may affect liver function, resulting in elevated liver enzyme levels. When taking for long periods, it is essential to follow the doctor's instructions, and if diarrhea occurs, dosing should be stopped immediately, and a doctor consulted. It is also advised to avoid using laxatives concurrently with this medication. For liver health, signs of liver damage should be carefully monitored, especially when used with other medications affecting the liver. Limiting alcohol consumption is also advisable. This medication may have reduced absorption when taken with antacids containing calcium, magnesium, and aluminum or with salts, so it should be taken at least 2 hours apart from these drugs. Furthermore, using it together with diuretics may strengthen diuretic effects, increasing the risk of dehydration and hypokalemia, so caution is necessary. When combined with heart glycosides, there may be an increased risk of arrhythmias. Pregnant or breastfeeding women are advised against taking this medication as animal studies have reported delays in fetal bone formation, and it may transfer in small amounts through breast milk. In case of overdose, severe diarrhea may occur, and appropriate treatment such as electrolyte supplementation should be undertaken.

Diarrhea, watery stools, abdominal pain, gastrointestinal disorders (bleeding, ulcers, and perforation), pigmentation of the rectal mucosa, dehydration, fluid and electrolyte imbalance, itching, rash, eczema, elevated serum liver enzymes

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is best to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. Proper storage can help preserve the medication's efficacy.

Appearance

A hard capsule with an upper yellow and lower pale yellow color containing brownish powder.

Package unit

30 capsules/bottle, 300 capsules/bottle