Harunick Injection (Sodium Hyaluronate) (Pre-filled)

Adult administration

Typically, for adults, 1 vial is administered intra-articularly in the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or bicipital tendon sheath) once a week for 3 consecutive weeks, but the frequency may be adjusted according to symptoms.

This medication should not be used in patients who have previously experienced allergic reactions to its components. It should be used with caution in patients with a history of allergies to other medications, liver dysfunction, or who have had liver disease in the past, as cases of liver dysfunction have been reported. Additionally, patients with skin diseases or infections at the injection site should have their conditions checked before administering this medication, as it is injected directly into the joint. Severe allergic reactions, including shock, may occur after administration, so the patient's condition should be closely monitored. If any unusual symptoms appear, administration should be stopped immediately and appropriate treatment should be sought. Other allergic symptoms, such as facial or periorbital swelling, rashes, or itching may occur, and administration should also be halted and treatment sought in such cases. Temporary pain, swelling, redness, warmth, or severe pressure at the injected joint site may occur, as well as symptoms like nausea, vomiting, or fever. In patients with severe arthritis, it is advisable to control inflammation before administering this medication. After administration, the injection site should be stabilized. If the drug leaks outside the joint, it can cause pain, so it must be injected accurately into the joint. This medication should only be injected in a sterile environment, and only up to 3 doses are recommended if symptoms do not improve. If there is excess joint fluid, it may be drained before administration as needed. Intra-vascular administration is prohibited, and it is not suitable for ocular use. A needle gauge of 22-23 is recommended, and caution should be taken as mixing with specific disinfectants can cause precipitation. The safety of this medication in pregnant women or women of childbearing age has not been established, so it should be used cautiously only when the benefits outweigh the risks. Furthermore, this medication can be transmitted through breast milk, so breastfeeding should be avoided during administration. The safety in children has not been adequately confirmed, thus it should only be used cautiously when absolutely necessary. Elderly patients may have reduced physiological functions, so special caution is advised during use.

Serious side effects

• Severe allergic reactions such as hives
• severe swelling (facial, eyelids, etc.)
• or shock symptoms

Mild side effects

• Facial swelling
• facial flushing
• rash
• itching
• pain
• swelling
• edema
• redness
• warmth
• local pressure sensation

This medication should be stored in a sealed container to prevent air or moisture from entering, and it is safest to keep it at room temperature between 1 to 30 degrees Celsius. Thus, avoid places that are too hot or too cold, and it is advisable to keep it in a place that maintains an appropriate temperature.

Appearance

A colorless, transparent, and viscous liquid contained in a glass or plastic vial sealed at both ends with rubber stoppers (part of the pre-filled syringe system)

Package unit

2.0 milliliters/vial × 3