Loxofen M Tablet (Sodium Loxoprofen Hydrate)

Adult dose

1. For indications 1 and 2: ○ Adults: Administer 60 mg of sodium loxoprofen (anhydrous) orally three times a day. In a single-dose treatment, administer 60–120 mg orally. 2. For indication 3: ○ Adults: Administer 60 mg of sodium loxoprofen (anhydrous) orally. In principle, it can be administered twice a day, with a maximum of 180 mg per day. It is preferable to avoid taking it on an empty stomach.

This drug is a nonsteroidal anti-inflammatory and analgesic with antipyretic effects. Individuals who regularly consume more than three drinks a day should consult a doctor or pharmacist before taking this medication due to the risk of gastrointestinal bleeding. Patients with cardiovascular diseases or risk factors may have an increased risk of serious cardiovascular problems, such as myocardial infarction or stroke, while using this medication; caution is advised. Doctors and patients should closely monitor for cardiovascular symptoms and be prepared to respond immediately if symptoms arise. This medication can cause serious gastrointestinal adverse reactions such as bleeding, ulcers, and perforations. Particularly, elderly patients or those with a history of gastrointestinal disease should be cautious, and consult a doctor immediately if symptoms such as abdominal pain, bloody stools, or vomiting occur. Patients with a history of peptic ulcers, severe blood disorders, liver disorders, kidney disorders, heart failure, or allergic reactions to this medication or its components should not take it. Patients who have experienced asthma or allergic reactions due to aspirin or other nonsteroidal anti-inflammatory drugs should also avoid using this medication. Patients with a history of peptic ulcers, blood disorders, liver or kidney dysfunction, elderly patients, and hypertension patients, should exercise special caution while taking this medication and adjust the dose as per the doctor's instructions if necessary. During the use of this drug, hypersensitivity reactions such as skin rashes, itching, or fever may occur, and in severe cases, hives or shock symptoms can manifest; therefore, if symptoms appear, stop taking it immediately and consult a healthcare professional. Gastrointestinal side effects such as abdominal pain, nausea, vomiting, and diarrhea may occur, with severe cases leading to gastrointestinal bleeding, ulcers, or intestinal perforation, so treatment should be sought immediately for abnormal symptoms. Psychoneurological symptoms such as drowsiness, dizziness, and headache may occur, while blood-related issues such as anemia or leukopenia are reported rarely. Liver function abnormalities may arise, thus, if jaundice or elevated liver function test values are detected, discontinue use; and there is a possibility of affecting kidney function, so be cautious of signs of renal failure. This drug should not be taken with other nonsteroidal anti-inflammatory drugs due to an increased risk of adverse reactions, and it may also interact with certain antibiotics, hypoglycemic agents, diuretics, anticoagulants, etc., so any medications being taken should be reported to your physician or pharmacist. During late pregnancy, there is a risk of ductus arteriosus closure in the fetus, so it should not be taken; in early or mid-pregnancy, it should only be used at the minimum dose for a short period if absolutely necessary. Breastfeeding women are advised not to take this medication, and its safety in children has not been established, thus usage is not recommended. Elderly patients should be especially cautious as the risk of side effects increases with this medication. It should be kept out of reach of children. This medication should be used at the minimum effective dose for the shortest possible duration, and it is important to consult healthcare professionals immediately if any abnormal symptoms appear.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, shock, anaphylactic-like symptoms, gastrointestinal bleeding, gastric bleeding, perforation, severe skin adverse reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, mucocutaneous syndrome, erythema multiforme, acute generalized exanthematous pustulosis), severe respiratory abnormalities (asthmatic attacks, difficulty breathing), liver abnormalities (liver dysfunction, jaundice, fulminant hepatitis, liver necrosis, liver failure), kidney abnormalities (acute renal failure, nephrotoxicity)

Mild side effects

• Rash
• itching
• fever
• abdominal pain
• epigastric discomfort
• loss of appetite
• nausea
• vomiting
• diarrhea
• constipation

This medication should be stored in a tightly sealed container to protect it from air and moisture. The storage temperature should ideally be maintained between 1 and 30 degrees Celsius (room temperature).

Appearance

Round tablet, white to pale yellow in color

Package unit

30 tablets/bottle, 100 tablets/bottle, 500 tablets/bottle