Ogutine Tablet 375 mg (Amoxicillin Trihydrate and Clavulanate Potassium)

Adult dose

Adults and children aged 12 years and older or weighing 40 kg or more should take amoxicillin/clavulanate potassium at a dosage of 250 mg/125 mg orally, three times a day every 8 hours. In cases of severe or respiratory infections, the dose may be increased to 500 mg/125 mg per administration. In cases of renal impairment, the dosage should be adjusted based on creatinine clearance. - Creatinine clearance 10 to 30 mL/min: Amoxicillin should be taken as 250 to 500 mg orally, every 12 hours. - Less than 10 mL/min: Amoxicillin should be taken as 250 mg orally, every 24 hours, ensuring the total dose does not exceed the recommended limit. - For children: Dosages should be adjusted accordingly using the same methods.

Child dose

For children aged 12 years and older or weighing 40 kg or more, the dosage is the same as for adults. In children with renal impairment, dosage should be reduced accordingly.

This medication contains a component that belongs to the beta-lactam class of antibiotics, specifically in the penicillin family. Therefore, patients with hypersensitivity to this medication's components, penicillin, or cephalosporin antibiotics should not use it. Patients with a history of severe allergic reactions such as anaphylaxis, Stevens-Johnson syndrome, or shock should also avoid this medication. Additionally, patients with certain viral infections such as infectious mononucleosis or lymphocytic leukemia may have an increased risk of rash and should be cautious. It is also advisable for patients with a history of liver dysfunction or jaundice to avoid this medication as it may exacerbate symptoms. In patients with impaired liver function or moderate to severe renal impairment, the excretion of this medication may be delayed, requiring careful determination of dosage adjustments and administration intervals. Patients with allergic constitutions or the elderly and those in poor general condition may be at higher risk of side effects and should be closely monitored. This medication may cause gastrointestinal symptoms such as diarrhea, nausea, vomiting, and abdominal pain; in rare cases, it may lead to pseudomembranous colitis or acute pancreatitis. If these symptoms worsen or if blood is present in the stool, the medication should be discontinued immediately and a healthcare provider consulted. Liver dysfunction may lead to hepatitis or jaundice, especially observed more frequently in elderly individuals over 60 years of age or in males. Serious skin reactions such as rashes, urticaria, or Stevens-Johnson syndrome should result in prompt discontinuation of the medication if abnormal symptoms occur. Additionally, blood disorders such as leukopenia, thrombocytopenia, and anemia have been reported rarely, and central nervous system effects such as dizziness or seizures may occur. Renal function abnormalities are also rare, necessitating regular monitoring. This medication may interact with other drugs, particularly anticoagulants, anti-inflammatory drugs, certain antibiotics, and immunosuppressants; caution is advised during concurrent use. For women who are pregnant or breastfeeding, the safety of this medication has not been fully established, so it is essential to consult a healthcare provider before deciding on its use. In children, especially those under 12 years of age or weighing less than 40 kg, there is limited experience with use and should be avoided. In the elderly, the risk of side effects may be higher due to decreased physiological functions, necessitating careful adjustment of the dosage and intervals. In case of overdose, symptoms such as vomiting, diarrhea, rash, and seizures may occur; medication should be discontinued immediately and appropriate emergency care sought. This medication should be stored in a tightly sealed container, protected from moisture, and kept in a cool, dry place below 25 degrees Celsius. It is important to use only for the necessary duration after susceptibility testing to prevent the emergence of resistant strains. If experiencing worsening diarrhea or abdominal pain while taking this medication, consult a healthcare provider immediately. If allergic symptoms or skin rashes occur, discontinue use and follow the healthcare provider's instructions.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweats, paleness, serious allergic reactions, severe rash accompanied by high fever, blisters, skin peeling, pain in mouth/eye mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, breathing problems, yellowing of skin or eyes (jaundice), profound malaise, liver abnormality (jaundice), sudden symptomatic

Mild side effects

• Diarrhea
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain
• abdominal distension

This medication should be kept in a sealed container to prevent moisture and stored in a cool, dry place below 25 degrees Celsius. This storage method helps maintain the medication's effectiveness and safety over time.

Appearance

Oval film-coated tablets, white or nearly white

Package unit

100 tablets (10 tablets/PTP × 10)