Bonhyal Plus Injection (Sodium Hyaluronate)

Adult administration

Typically, 1 syringe is administered once a week for 3 consecutive weeks into the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or biceps brachii tendon sheath). The frequency of administration should be adjusted according to symptoms.

This medication should not be used in patients who have experienced allergic reactions to its components. Patients with allergies to other medications, impaired liver function, or a history of liver disease should be cautious when using this medication, as cases of liver function impairment have been reported. Additionally, caution should be exercised when using this medication in the presence of skin diseases or infections at the injection site, as it is administered directly into the joint. Serious allergic reactions such as shock may occur, so the patient's condition should be closely monitored during treatment. If abnormal symptoms occur, use should be discontinued immediately, and appropriate treatment should be sought. Other possible hypersensitivity reactions include swelling in the face or around the eyes, rashes, hives, or itching. If these symptoms occur, discontinue medication and inform the hospital. Temporary pain, swelling, redness, heat, or severe pressure may occur at the injection site; if these symptoms occur, consult a physician. Occasionally, symptoms such as nausea, vomiting, and fever may also occur, so caution is necessary. For patients with severe inflammatory arthritis, it may be advisable to reduce inflammation before administering this medication, as using it in a highly inflamed state may exacerbate symptoms. After administering this medication, stabilizing the affected area can be helpful. If the medication leaks outside the joint, it can cause pain, so it must be injected accurately into the joint cavity. It is very important to maintain an aseptic condition during injection, and treatment should be discontinued after three doses if symptoms do not improve. If there is a significant accumulation of joint fluid, it may be necessary to remove the fluid before injection. This medication should not be administered intravenously or for ophthalmic use, and it is advisable to use a needle gauge of about 22-23. Attention should be paid to avoid using it with certain disinfectants such as benzalkonium chloride or chlorhexidine, as it may cause the drug to precipitate. Use during pregnancy or in women who may become pregnant is not safely established; therefore, it should be administered cautiously only when the benefits outweigh the risks. Moreover, this medication may be transmitted through breast milk, so breastfeeding should be avoided during treatment. When using this medication in children, safety has not been established, so it should only be used cautiously when necessary. Elderly patients may have decreased bodily function; caution is recommended when using this medication.

Serious side effects

• Hives
• swelling
• shock symptoms

Mild side effects

• Swelling (facial, eyelid, etc.)
• facial erythema
• rash
• itching
• pain (transient)
• edema
• redness
• heat
• severe localized pressure
• nausea

This medication should be stored in a sealed container to protect it from air and moisture. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

A colorless, transparent, and viscous liquid contained in a glass or plastic syringe that is sealed with rubber stoppers on both ends (part of a prefilled syringe system).

Package unit

2 milliliters/prefilled syringe [2mL x 3 syringes]