Janumet XR Extended-Release Tablet 100/1000 mg

Adult dose

The 100/1000 mg extended-release tablet should be taken once daily, 1 tablet at a time. Patients taking the 50/500 mg or 50/1000 mg extended-release tablets should take 2 tablets at once once daily. 1. Patients not currently treated with metformin: The initial dose is 100 mg of sitagliptin and 1000 mg of metformin administered as a total daily amount. If sufficient blood sugar control is not achieved, consider titrating up to the maximum recommended daily dose of metformin, which is 2000 mg, to reduce gastrointestinal side effects. Patients with reduced renal function taking decreasing doses of sitagliptin should not be switched to this medication.

This medication is used in the treatment of Type 2 diabetes and contains sitagliptin and metformin. Serious allergic reactions may occur during treatment, so if symptoms such as skin rashes, hives, or difficulty breathing develop, stop taking the medication immediately and consult a doctor. There is a risk of acute pancreatitis, characterized by inflammation of the pancreas; inform healthcare providers immediately if symptoms such as abdominal pain, vomiting, or nausea appear. The medication can pose a risk to patients with decreased kidney function, so regular kidney function tests are necessary, and the medication should be discontinued if kidney function deteriorates. Rare but life-threatening lactic acidosis may occur due to the metformin ingredient; seek immediate medical attention if severe fatigue, muscle pain, difficulty breathing, or abdominal pain occurs. The medication may also cause hypoglycemia, so regular meals and exercise are important to avoid skipping meals or irregular eating. Women who are pregnant, may become pregnant, or are breastfeeding should not take this medication, and its safety has not been established for children under the age of 18. The risk of side effects may increase when this medication is taken with alcohol, so it is advisable to avoid drinking. If surgery is planned, the medication should be discontinued 48 hours prior to surgery and should only be resumed after confirming normal kidney function post-surgery. Interactions with other medications may occur, so inform healthcare providers of any other medications being taken. Regular monitoring of blood sugar, kidney function, and vitamin B12 levels is necessary to detect abnormalities early. In cases of overdose, seek medical attention immediately, as the drug can be partially removed through hemodialysis.

Serious side effects

Hives, severe allergic reactions (anaphylaxis, angioedema, Stevens-Johnson syndrome), acute pancreatitis, severe lactic acidosis, hypoglycemia, severe edema, hypertension, acute renal failure, liver abnormalities (liver dysfunction, jaundice), severe skin reactions (severe rash, blisters, skin peeling, pain of mucous membranes in mouth/eyes), respiratory issues (difficulty breathing, asthma attacks, cough with fever), severe neurological symptoms (e.g., tremors).

Mild side effects

Diarrhea, upper respiratory infection, headache, nausea, vomiting, abdominal pain, constipation, nasopharyngitis, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, hypoglycemia, joint pain associated with severity and disability, rhabdomyolysis, elevated liver enzymes, vitamin B12 deficiency, etc.

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is important to maintain a storage temperature between 1°C and 30°C.

Appearance

A film-coated tablet that is oval in shape, convex on both sides, bright blue in color with '81' etched on one side.

Package unit

28 tablets/bottle