Janumet XR Extended-Release Tablet 50/1000 mg

Adult dose

The 100/1000 mg extended-release tablet of this medication should be taken once daily, with one tablet per dose. Patients taking the 50/500 mg extended-release tablet or the 50/1000 mg extended-release tablet should take two tablets at once, once a day. 1. For patients not currently receiving treatment with metformin: The initial dose is sitagliptin 100 mg and metformin 1000 mg as a total daily amount. Gradually increase the dose of metformin.

This medication contains sitagliptin and metformin, used for blood sugar control. While taking this medication, serious allergic reactions may occur; if symptoms such as rash, itching, or difficulty breathing appear, discontinue use immediately and consult a healthcare professional. Serious pancreatic inflammation, known as pancreatitis, may rarely occur, so if symptoms such as abdominal pain, nausea, vomiting, or fever occur, visit a hospital immediately. Do not take this medication if you have severely compromised kidney function, dehydration, serious infections, or heart disease. If undergoing tests using iodinated contrast agents, you must stop this medication for a certain period before and after the test, and restart only after confirming that kidney function is normal. It is safest for pregnant women, women who may become pregnant, and nursing mothers not to take this medication. This medication may cause hypoglycemia, so when skipping meals or having irregular meals, excessive exercise, or taking other glucose-lowering agents, blood sugar levels should be carefully monitored. Patients with impaired liver function or those who consume alcohol excessively may be at risk of developing lactic acidosis, a serious metabolic anomaly, hence should avoid taking this medication. Regular monitoring of kidney function and vitamin B12 levels in the blood is important to ensure they remain normal. Patients scheduled for surgery should stop taking this medication 48 hours before surgery, and only resume after recovery of oral intake and confirmation of normal kidney function. This medication has not been adequately confirmed for safety and efficacy in children, so it is advisable not to use it in pediatric patients under 18 years of age. Elderly patients may have decreased kidney function, so dose adjustments and regular kidney function monitoring are necessary when taking this medication. In case of overdose of this medication, appropriate treatment should be sought immediately from a medical facility, and since blood dialysis may be necessary, swift response is important.

Serious side effects

Urticaria, angioedema, anaphylaxis, Stevens-Johnson syndrome, cutaneous vasculitis, exfoliative skin disease, acute pancreatitis, acute renal failure, severe hypoglycemia, arthritis with severe or disabling symptoms, blistering pemphigoid, lactic acidosis, liver dysfunction (liver impairment), severe edema, acute renal failure, severe allergic reactions.

Mild side effects

Diarrhea, upper respiratory infection, headache, nausea, vomiting, abdominal pain, nasopharyngitis, constipation, myalgia, limb pain, back pain, pruritus, thrombocytopenia, rhabdomyolysis, hypoglycemia, arthritis without severe or disabling symptoms, hypoglycemia.

This medication should be stored in an airtight container as it is sensitive to air and moisture. The storage temperature should maintain room temperature between 1 to 30 degrees Celsius. This will help retain the medication's efficacy for an extended period.

Appearance

A biconvex oval film-coated tablet that is bright green with '80' engraved on one side

Package unit

28 tablets/bottle, 56 tablets/bottle