Janumet XR Extended-Release Tablet 50/500 mg

Adult dose

The dosage for this medication is determined based on the patient's condition, within the range of sitagliptin 100 mg and metformin 2000 mg. This medication is taken once daily in the evening with meals, with gradual increases in dosage. The extended-release tablets should be swallowed whole without splitting or crushing. For the 100/1000 mg extended-release tablets, take 1 tablet once daily; for the 50/500 mg or 50/1000 mg extended-release tablets, take 2 tablets once daily.

This medication contains sitagliptin and metformin and is used in the treatment of diabetes. However, serious hypersensitivity reactions may occur while taking this medication, so if signs of anaphylaxis, angioedema, or severe skin reactions appear, discontinue immediately and consult a doctor. There have also been reports of acute pancreatitis, so if symptoms such as abdominal pain, vomiting, or fever occur, notify healthcare personnel immediately. This medication should not be taken by patients with moderate to severe renal impairment or in unstable physical conditions such as acute heart failure or severe infections, and it should be discontinued before and after tests using iodinated contrast agents. It is safe for pregnant or breastfeeding women to avoid taking this medication. The risk of hypoglycemia exists with this medication, so blood glucose levels should be monitored carefully during irregular meals or vigorous exercise. Regular kidney function and blood tests should be conducted during treatment, especially for older patients or those with reduced kidney function. Additionally, the metformin component may rarely cause serious side effects such as lactic acidosis, so if symptoms such as abdominal pain, difficulty breathing, or lethargy occur, visit the hospital immediately. Avoid excessive alcohol intake during treatment, and it is important to inform healthcare personnel of all medications being taken due to potential interactions.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, rash, severe allergic reactions, severe skin adverse reactions (Stevens-Johnson syndrome, exfoliative dermatitis), fatal or non-fatal hemorrhagic and necrotizing pancreatitis, acute pancreatitis, liver abnormalities (elevated liver enzymes, jaundice), sudden and extremely severe headaches, seizures, confusion, visual disturbances, paralysis, acute renal failure, significant decrease in urine output.

Mild side effects

Diarrhea, upper respiratory infection, headache, nausea, vomiting, abdominal pain, nasopharyngitis, muscle pain, limb pain, back pain, interstitial lung disease, pruritus, thrombocytopenia, rhabdomyolysis, vitamin B12 deficiency, hypoglycemia, severe and disability-associated joint pain, bullous pemphigoid.

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it is important to store this medication at a temperature between 1 and 30 degrees Celsius to maintain its efficacy.

Appearance

Light blue, biconvex oval film-coated tablet with '78' engraved on one side.

Package unit

28 Tablets/Bottle, 56 Tablets/Bottle