Gluris M Tablets (Glibenclamide, Metformin Hydrochloride)

Adult dose

This medication is administered 1 to 2 times a day before meals or with meals. Usually, treatment is started at a low dose, and the dosage can be adjusted considering the patient's current medications and blood glucose levels. In clinical trials, the initial daily dose was 2 mg of glibenclamide/500 mg of metformin hydrochloride, and based on blood glucose monitoring results, the dose was gradually increased up to 8 mg/2000 mg. For monotherapy, glibenclamide is generally not effective at doses above 4 mg, but some patients showed better metabolic control by increasing the dose to 6 mg (or 8 mg). When used as an alternative therapy in combination therapy, it should be administered based on the current dosages of glibenclamide and metformin hydrochloride. If a previous dose has been missed, the next dose should not exceed the prescribed dosage.

This medication can cause severe lactic acidosis or hypoglycemia, so caution is needed. In particular, if kidney function suddenly declines, the drug may accumulate in the body, increasing the risk of lactic acidosis. If dehydration symptoms occur, the medication should be temporarily discontinued, and a doctor should be consulted. Caution is also needed when taking other drugs that affect kidney function. This medication should not be administered to patients with insulin-dependent diabetes or acute metabolic acidosis. It should also not be used in patients with severely impaired liver function, pregnant women, or nursing mothers. The elderly may experience reduced kidney function, so dosage adjustments and regular kidney function tests are necessary. Patients at high risk of hypoglycemia, those with irregular meals or alcohol intake, and patients with impaired liver function should be particularly cautious when taking this medication. Gastrointestinal symptoms may appear at the beginning of treatment, but they are mostly temporary and can be alleviated by taking the medication with meals. If an allergic reaction or severe side effects occur, consult a doctor immediately. This medication can interact with other drugs, so it is essential to inform the healthcare provider of any medications being taken. Women who are pregnant or planning to become pregnant are advised to use insulin treatment instead of this medication. Safety and efficacy have not been adequately confirmed in children or adolescents, so caution is needed. Overdose may lead to hypoglycemia or lactic acidosis, requiring immediate medical assistance. While taking this medication, it is necessary to maintain regular meals and exercise, as well as regular monitoring of blood glucose and kidney function. Caution should also be taken when driving or operating machinery due to the risk of hypoglycemia.

Serious side effects

Hives, severe swelling (edema), shortness of breath, chest tightness, cold sweat, pallor, severe allergic reactions, high fever with severe rash, blisters, skin peeling, pain in mouth/eye mucosa, severe dermatological reactions, difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice of the skin or eyes, general malaise, liver abnormalities, sudden and very severe headaches, thunderclap headaches, seizures, unconsciousness.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, taste disturbances, metallic taste, visual impairment, taste abnormalities, decrease in serum vitamin B12 levels, peripheral neuropathy due to vitamin B12 deficiency, increased intrahepatic enzymes, liver function impairment, hepatitis, allergic vasculitis, skin reactions.

This medication should be stored in a sealed container to prevent air from entering and is recommended to be stored at room temperature between 1 to 30 degrees Celsius. By storing it this way, the effectiveness of the medication can be maintained, and it can be used safely.

Appearance

White oblong film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle