Dikrifin Sustained Release Tablet 5mg (Felodipine)

Adult dose

Swallow this medicine whole with water. Do not divide, chew, or crush it. Hypertension: The initial dose is 5㎎ of felodipine orally once daily, and the maintenance dose is 5-10㎎ once daily in the morning. Do not exceed 20㎎ per day. This medicine may be administered concomitantly with a β-blocker or diuretic, or as monotherapy if other antihypertensive agents are unsuitable. Adjust the dose according to the patient's response to treatment. Stable angina: The initial dose is 5㎎ once daily and may be increased to 10㎎ as needed. This medicine may be administered concomitantly when a β-blocker does not provide an adequate effect. Adjust the dose according to the patient's response to treatment. Older adults: Administer with caution while monitoring the patient's condition, considering an initial dose of 2.5㎎ once daily. Patients with renal impairment: Renal impairment does not affect the plasma concentration of felodipine. No dose adjustment is necessary, but administer with caution to patients with severe renal impairment (GFR<30ml/min). Patients with hepatic impairment: Plasma concentrations of felodipine may increase in patients with hepatic impairment, and they may respond to treatment at lower doses. Therefore, administer with caution to patients with hepatic impairment, considering an initial dose of 2.5㎎ once daily; do not administer to patients with severe hepatic impairment.

Child dose

Pediatric patients: Safety and efficacy in pediatric patients have not been established.

This medication should not be administered to women who are pregnant or may become pregnant. It is also advisable not to use it in patients with cardiogenic shock or severely impaired heart function. Additionally, patients who have had an allergic reaction to this medication or those with certain heart valve diseases should avoid taking it. It is also recommended not to administer it to patients with very poor liver function or those with acute myocardial infarction or unstable angina. Elderly patients, those with heart failure, hypotension, liver dysfunction, and severely reduced kidney function should be cautiously administered this medication. Moreover, patients who are allergic to the color additive Yellow No. 5 in this medication should also use it with caution. When taking this medication for the first time or increasing the dose, symptoms such as facial flushing, headaches, palpitations, dizziness, and fatigue may occur. These symptoms are generally temporary and may vary depending on the dosage. Rarely, symptoms such as palpitations, tachycardia, shortness of breath, chest tightness, ankle edema, and symptoms of angina may occur, and if they are severe, the patient should consult a physician. Headaches, dizziness, drowsiness, lethargy, nausea, constipation, abdominal pain, loss of appetite, diarrhea, dry mouth, and vomiting may also occur. If dental health is poor, symptoms of gingivitis or gingival hyperplasia may appear, so oral hygiene should be taken care of. If signs of liver dysfunction appear, administration should be stopped, and medical attention should be sought. Appropriate actions are also required if symptoms of kidney dysfunction or anemia appear. If allergic reactions such as skin rash, itching, hives, facial flushing, photosensitivity, or swelling of the lips or tongue occur, the medication should be stopped immediately. Rarely, various side effects such as muscle pain, joint pain, high blood sugar, weight gain, peripheral edema, fatigue, cough, conjunctival injection, and sexual dysfunction may occur. Stopping this medication abruptly may worsen symptoms, so the dosage should be gradually reduced according to the physician's instructions, and it should not be discontinued arbitrarily. If the blood pressure drops too low, dizziness may occur, so caution should be exercised when driving or operating hazardous machinery. It is advisable to take this medication in the morning, and it can be taken on an empty stomach or after a light meal. This medication is metabolized by a specific enzyme (CYP3A4) in the liver, so caution is needed when taken with other medications that inhibit or activate this enzyme, as it may alter blood concentration. In particular, it should be avoided or taken under medical advice when combined with certain antibiotics, antifungals, antivirals, some anticonvulsants, and grapefruit juice. Safety during pregnancy has not been clearly established, so pregnant women should not take this medication, and during breastfeeding, administration should be avoided if possible or breastfeeding should be discontinued. Safety in pediatric patients has not been established, so its use in children is not recommended. Elderly patients are at risk of reduced blood pressure leading to stroke, so they should start on low doses and their condition should be monitored closely. In case of overdose, serious symptoms such as low blood pressure, cardiac arrhythmias, consciousness disorders, and respiratory distress may occur, so emergency treatment should be sought immediately. If dizziness or fatigue occurs during the use of this medication, driving or machine operation should be avoided, and consultation with a physician should be made if any unusual symptoms arise.

• Facial flushing
• headache
• palpitations
• dizziness
• fatigue
• tachycardia
• feeling of suffocation
• chest tightness
• ankle edema
• angina

This medication should be stored in an opaque container to prevent light exposure and should be kept in a sealed container that blocks air. It is important to maintain a storage temperature between 1 to 30 degrees Celsius at room temperature.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle