Plavix Tablet (Clopidogrel Bisulfate)

Adult dose

1. In patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, clopidogrel should be administered orally at a dose of 75 mg once daily. 2. In patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), initiate with a loading dose of 300 mg orally once on the first day of treatment, followed by a maintenance dose of 75 mg orally once daily.

This medication prevents platelets from aggregating, thereby preventing blood clotting. Individuals with a genetic deficiency in the specific enzyme (CYP2C19) may have reduced effectiveness of this medication; alternative treatment options should be considered in such cases. Additionally, caution is advised if this medication is taken in combination with drugs that activate the CYP2C19 enzyme, as this can increase the risk of bleeding due to excessive efficacy. Patients allergic to this medication or its ingredients, those with bleeding disorders, severely impaired liver function, women who are breastfeeding, or individuals with certain genetic disorders should not use this medication. Patients at high risk of bleeding or those scheduled for surgery should consult with a physician about the need to discontinue or adjust the medication. During treatment, it may be easy to experience bleeding; therefore, if any bleeding symptoms occur, medical personnel should be informed immediately. Extra caution is warranted when taken concurrently with other medications that increase the risk of bleeding. Rarely, prolonged use of this medication may lead to serious blood disorders. Therefore, if any symptoms of infection or abnormal symptoms appear, immediate medical attention should be sought. It is known that there is minimal effect on the fetus during pregnancy; however, the risk of bleeding may increase during delivery, and discontinuation of the medication before childbirth is advisable. If breastfeeding, consult with a physician about whether to continue or discontinue breastfeeding, as this medication may be excreted in breast milk. Safety in children has not been established, and in the elderly, caution is advised due to increased bleeding risk. Overdosing may increase the risk of bleeding; hence, it is crucial to adhere to the prescribed dosage and administration. This medication should be stored out of reach of children and not transferred to another container.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mouth/eye mucosa, difficulty breathing or shortness of breath, asthma attacks, respiratory difficulties accompanied by cough and fever, jaundice indicating yellowing of skin or eyes, extreme lethargy, sudden severe headache, thunderclap headache, seizure, altered consciousness, visual abnormalities, paralysis, and urinary issues.

Mild side effects

• Headache
• dizziness
• abdominal pain
• indigestion
• diarrhea
• nausea
• fatigue
• rash
• pruritus
• arthralgia

This medication should be stored in a tightly closed container to protect it from air and moisture. It is also advisable to store the medication at room temperature, which is between 1 to 30 degrees Celsius, avoiding extreme temperatures.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle