Clopidogrel Tablets (Clopidogrel Sulfate)

Adult dose

For patients with ischemic stroke, myocardial infarction, or peripheral artery disease, administer clopidogrel as 75 mg orally once daily. For patients with acute coronary syndrome (unstable angina or non-ST elevation myocardial infarction), start with a loading dose of 300 mg orally once daily on the first day of treatment and then maintain with 75 mg orally once daily thereafter. At this time, aspirin 75 to 325 mg should be administered daily.

This medication prevents the aggregation of platelets, preventing blood from clotting. Patients with genetically reduced function of a specific enzyme (CYP2C19) may experience reduced effectiveness of this medication, and in such cases, alternative treatment methods should be considered. Furthermore, using medications that activate this enzyme together with this medication may increase the concentration of the drug and raise the risk of bleeding; therefore, it is advisable not to take them together. This medication should not be used in individuals with hypersensitivity, those with bleeding, severe liver damage, nursing women, or individuals with lactose intolerance. Patients at high risk of bleeding or those scheduled for surgery should use this medication cautiously and may need to discontinue it 5 to 7 days before surgery. There is an increased risk of bleeding when this medication is taken with other bleeding-risk medications, so caution is advised. If any bleeding symptoms occur during treatment, it is essential to inform a doctor immediately and to notify medical professionals of the use of this medication before surgery or starting new medications. It is important to regularly check for bleeding or blood abnormalities through blood tests while taking this medication. Additionally, thrombocytopenia or severe blood disorders may occur rarely, so if symptoms of infection or unusual symptoms arise, consult healthcare professionals immediately. This medication may cause gastrointestinal disturbances, skin rashes, headaches, and dizziness, and rarely serious bleeding or allergic reactions may occur. While the risk to the fetus during pregnancy is low, it is recommended to discontinue the medication before delivery due to the risk of bleeding at childbirth. Nursing women should consider stopping breastfeeding or discontinuing the medication as it is uncertain whether this medication is secreted in breast milk. The safety and efficacy in children have not been established, and elderly patients should be observed carefully due to a higher risk of bleeding during use. In case of overdose, bleeding time may be prolonged, and the risk of bleeding may be increased, necessitating measures such as platelet transfusion.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, feeling short of breath or difficulty breathing, asthma attacks, respiratory distress with cough and fever, yellowing of the skin or eyes (jaundice), extreme fatigue, sudden severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urinary disorders

Mild side effects

• Headache
• dizziness
• abdominal pain
• dyspepsia
• diarrhea
• nausea
• rash
• pruritus
• fatigue
• joint pain

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, ideally at room temperature between 1 and 30 degrees Celsius. Storing it in this manner will help maintain the medication's efficacy.

Appearance

Pink, round, film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle