Olmesartan Medoxomil 20mg Tablets

Adult dosage

The recommended initial dose is 10mg once daily, administered regardless of meals. If blood pressure is not adequately controlled at this dose, it may be increased to 20mg once daily. If additional blood pressure reduction is needed, the dose may go up to a maximum of 40mg once daily. The blood pressure-lowering effect appears within 2 weeks of starting treatment and reaches maximum effectiveness after approximately 8 weeks. If blood pressure is not controlled with monotherapy, thiazide diuretics such as hydrochlorothiazide may be co-administered. To improve adherence, it is recommended to take it at the same time daily (e.g., in the morning). Patients who may have a reduction in effective blood volume (e.g., those on diuretics, especially with kidney impairment) should start treatment at a lower dose with sufficient monitoring.

Children's dosage

Safety and efficacy in pediatric patients have not been established.

This medication can cause serious harm or death to fetuses and newborns if taken during the second and third trimesters of pregnancy, so it must be discontinued immediately if pregnancy is confirmed. Those with allergies to this medication, who are pregnant or breastfeeding, undergoing kidney dialysis, have severe liver impairment, biliary obstruction, or lactose intolerance should not take this medication. Patients with low blood volume or salt may experience hypotension when starting this medication, and caution should be exercised. Patients with weak kidney function or kidney transplant recipients should regularly monitor kidney function and electrolyte status through blood tests. Particularly, patients with unilateral or bilateral renal artery stenosis may be at increased risk of kidney function deterioration and should be cautious. This medication can cause hyperkalemia; therefore, patients with heart failure or poor kidney function should regularly check potassium levels in the blood. Patients with aortic or mitral valve stenosis and obstructive heart disease need to be particularly cautious when taking this medication. Low blood pressure may cause dizziness; therefore, it's advisable to avoid hazardous activities such as working at heights or operating vehicles. This medication has been used safely in most patients, with common side effects including dizziness, headache, back pain, indigestion, and chest pain, which are generally mild and transient. Occasionally, angioedema or facial swelling may occur, so any abnormal symptoms should prompt immediate consultation with medical personnel. When taken with other antihypertensive medications, the blood pressure-lowering effect may be enhanced, and caution is required if taken with potassium-sparing diuretics or potassium supplements, as this may dangerously elevate blood potassium levels. Coadministration with lithium preparations can increase lithium levels, potentially causing toxicity; thus, it should be avoided. When taken with non-steroidal anti-inflammatory drugs, kidney function may worsen, so attention should be given to fluid intake and kidney function monitoring. Taking this medication during pregnancy poses risks such as reduced fetal kidney function, oligohydramnios, and neonatal mortality; therefore, it should be stopped immediately upon confirmation of pregnancy. Breastfeeding women are advised to discontinue breastfeeding or the medication, as it may pass into breast milk. Safety in pediatric patients has not been established, so caution should be exercised when using in children. For the elderly, monitoring and dose adjustments are necessary, as this medication's body concentration may increase. Overdosing may result in symptoms like hypotension and palpitations; if symptoms are severe, immediate medical attention should be sought. This medication has been reported to have low risk of carcinogenicity or genotoxicity even with long-term use, but appropriate use according to body condition is important.

Serious side effects

Urticaria, severe swelling (angioedema), chest pain, angioedema, anaphylaxis, hyperkalemia, acute renal failure, increased serum creatinine, headache (severe headache, thunderclap headache), confusion, seizures, visual disturbances, paralysis, liver dysfunction (elevated liver enzymes and bilirubin, jaundice), hair loss, urticaria

Mild side effects

• Dizziness
• headache
• palpitations
• back pain
• bronchitis
• increased creatine kinase
• diarrhea
• hematuria
• hyperglycemia
• hypertriglyceridemia

This medication should be stored in a sealed container to prevent exposure to air and moisture and is best kept at room temperature between 1 degree and 25 degrees Celsius. This helps maintain the medication's effectiveness and ensures safe usage.

Appearance

White round film-coated tablets

Package unit

300 tablets/bottle, 30 tablets/bottle