Olmesartan Medoxomil 20 mg Tablets

Adult dose

The recommended initial dose is 10 mg once daily, taken regardless of meals. If blood pressure is not adequately controlled at this dose, it may be increased to 20 mg once daily. For additional blood pressure reduction, it can be increased up to a maximum of 40 mg once daily. The blood pressure-lowering effect usually appears within 2 weeks of starting treatment, with maximum effectiveness observed after about 8 weeks. If blood pressure is not controlled with this medication alone, it may be combined with thiazide diuretics such as hydrochlorothiazide. To improve adherence, it is recommended to take it at the same time each day (e.g., in the morning). For patients with potential intravascular volume depletion (e.g., those taking diuretics, especially renal patients), it is advised to start treatment at a low dose while monitoring closely. For elderly patients aged 65 and older, dose adjustment is not required. No overall difference in efficacy and safety has been observed between elderly and younger patients, but some elderly patients may show more sensitive responses. For patients with renal impairment, the maximum dosage for those with mild to moderate renal impairment (creatinine clearance 20-60 mL/min) is 20 mg once daily. For patients with liver impairment, patients with mild liver impairment do not require dose adjustment. For patients with moderate liver impairment, the recommended initial dose is 10 mg once daily, which can be increased up to 20 mg once daily. There is no experience with severe liver impairment; therefore, use is not recommended.

Child dose

The safety and efficacy in pediatric patients have not been established.

This medication can cause serious harm or death to the fetus and newborn if taken during pregnancy, particularly in the second and third trimesters, so it should be discontinued immediately if pregnancy is confirmed. Individuals with allergies to any of the ingredients in this medication, pregnant or nursing women, patients on renal dialysis, those with severe liver impairment, patients with bile duct obstruction, and certain hereditary lactose intolerant patients should not take this medication. Patients with decreased blood volume or insufficient sodium may experience low blood pressure, so their condition should be thoroughly evaluated before use, and prompt treatment should be sought if symptoms of low blood pressure occur. Patients with impaired kidney function or kidney transplant recipients should have their serum potassium and creatinine levels monitored regularly, and it is not recommended for patients with severe renal impairment. This medication has blood pressure-lowering effects, so caution is required for patients with aortic stenosis or mitral valve stenosis, and it may be less effective in patients with primary aldosteronism. Dizziness may occur during treatment, so it is advisable to avoid hazardous activities such as working at heights or driving. During treatment, caution should be taken when using potassium-sparing diuretics, potassium supplements, lithium, or non-steroidal anti-inflammatory drugs, as the risk of side effects may increase. Consult with a doctor regarding these combinations. If chronic diarrhea or weight loss occurs, this medication may be the cause, and immediate consultation with a healthcare professional is advised, and appropriate treatment should be sought if intestinal vascular edema symptoms develop. The safety and efficacy in pediatric patients have not been thoroughly established, and elderly patients may experience increased drug concentrations in the body, necessitating caution. Overdose may result in low blood pressure or palpitations; if symptoms are severe, immediate medical attention is required. Regular liver function and blood tests during treatment are important to detect and manage adverse reactions early. Nursing mothers should consult a doctor about the possibility of the drug being transmitted through breast milk and consider stopping breastfeeding or discontinuing the medication.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory distress accompanied by cough + fever, jaundice (yellowing of skin or eyes), profound malaise, sudden and severe headache, thunderclap headache, seizures, confusion, vision abnormalities, paralysis, urination changes

Mild side effects

• Dizziness
• headache
• palpitations
• hypercholesterolemia
• hyperlipidemia
• hyperuricemia
• arthralgia
• arthritis
• myalgia
• rash

Store this medication in a tightly closed container to protect it from air and moisture. It should be stored at room temperature, between approximately 1 degree and 25 degrees Celsius, away from extreme temperatures.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle