Medication info
Alitok Soft Capsule 10mg (Alitretinoin)

Alitok Soft Capsule 10mg (Alitretinoin)

Prescription medicationSoft capsuleOral
Ingredient · strength
Alitretinoin›10mg / 1 tablet
Manufacturer / importer
GSK Korea
Appearance
Brown oval soft capsule
Packaging
30 capsules (10 capsules/PTP x 3)
Approval status
Active

MFDS item code 201306906 · Approved 2013.04.15 · Insurance code 650003160

Summary

Main use
Treatment of chronic severe hand eczema in adults that has not responded to potent topical corticosteroids
Who takes it
Adults
Adult dose
Take 10~30mg once daily with or immediately after a meal. It is preferable to take this medicine at the same time each day. The initial dose is 30mg of alitretinoin; reduce the dose to 10mg depending on adverse reactions. Patients with diabetes, obesity, cardiovascular risk factors, or dyslipidemia : Start with an initial dose of 10mg and, if necessary, increase to 30mg according to tolerability and efficacy. Periodic monitoring of blood lipid profile and blood glucose may be necessary during treatment with this medicine. Stop treatment as soon as the treatment goal of clear or almost clear hands is achieved. If the severity of hand eczema remains severe after the initial 12 weeks of treatment, discontinue treatment. Also discontinue treatment if the treatment goal has not been achieved by week 24.

Ingredients

Importer
GSK Korea

Efficacy & effects

Treatment of chronic severe hand eczema in adults that has not responded to potent topical corticosteroids

  • Chronic severe hand eczema
View approved original text

This medication is used to treat chronic severe hand eczema in adults that does not respond to at least 4 weeks of potent topical steroid therapy.

How to take

Adult dose

Take 10~30mg once daily with or immediately after a meal. It is preferable to take this medicine at the same time each day. The initial dose is 30mg of alitretinoin; reduce the dose to 10mg depending on adverse reactions. Patients with diabetes, obesity, cardiovascular risk factors, or dyslipidemia : Start with an initial dose of 10mg and, if necessary, increase to 30mg according to tolerability and efficacy. Periodic monitoring of blood lipid profile and blood glucose may be necessary during treatment with this medicine. Stop treatment as soon as the treatment goal of clear or almost clear hands is achieved. If the severity of hand eczema remains severe after the initial 12 weeks of treatment, discontinue treatment. Also discontinue treatment if the treatment goal has not been achieved by week 24.

Precautions

This medication should not be used by pregnant women or women who may become pregnant. The risk of causing serious fetal malformations is very high, so thorough contraception is necessary before, during, and after treatment. Regular pregnancy tests should be conducted before and during treatment, and if pregnancy is confirmed, use should be discontinued immediately, and a doctor should be consulted. Serious issues such as acute pancreatitis may occur if triglyceride levels in the blood are high; therefore, triglycerides and cholesterol should be monitored regularly. It may affect mental health, so if symptoms of depression or mood changes occur, medical personnel should be notified immediately, and psychiatric treatment should be obtained if necessary. It is advisable to avoid excessive sun exposure during treatment and to use sunscreen. If there is dryness in the eyes or visual disturbances, this should be reported immediately, and glasses should be prepared as contact lens wear may become difficult. This medication should not be used if there are issues with liver or kidney function or certain allergy histories. It may interact with other medications, so if taking other drugs, it is essential to inform the doctor or pharmacist. This medication should be taken with food or immediately after meals and should be swallowed whole with water without chewing. Use is prohibited for children, pregnant women, and breastfeeding women, and the medication should be kept out of reach of children. In cases of overdose, symptoms such as severe headache, diarrhea, flushing, increased triglycerides may occur, so dosage must be strictly adhered to. While taking this medication, intense exercise should be avoided, and caution is needed for a certain period even after treatment ends.

Side effects

  • Headache
  • erythema
  • flushing
  • increased triglycerides
  • increased cholesterol
  • decreased thyroid-stimulating hormone
  • decreased free T4
  • anemia
  • increased iron binding capacity
  • decreased monocytes
Show 62 more
  • increased platelets
  • anaphylactic reaction
  • hypersensitivity reaction
  • depression
  • mood changes
  • suicidal thoughts
  • dizziness
  • benign intracranial hypertension
  • conjunctivitis
  • dry eyes
  • eye irritation
  • blurred vision
  • cataracts
  • decreased night vision
  • tinnitus
  • hypertension
  • vasculitis
  • nosebleeds
  • nausea
  • dry mouth
  • vomiting
  • dyspepsia
  • inflammatory bowel disease
  • increased aminotransferases
  • dry skin and lips
  • cheilitis
  • eczema
  • dermatitis
  • hair loss
  • pruritus
  • rash
  • skin peeling
  • dry eczema
  • nail disorders
  • phototoxic reactions
  • hair texture abnormalities
  • arthralgia
  • myalgia
  • exostosis
  • ankylosing spondylitis
  • fatigue
  • peripheral edema
  • hypertriglyceridemia
  • decreased HDL
  • hypercholesterolemia
  • increased serum creatine phosphokinase
  • diabetes
  • color blindness
  • contact lens intolerance
  • premature epiphyseal closure
  • hyperostosis
  • calcification of ligaments and tendons
  • corneal opacification
  • keratitis
  • inflammatory bowel disease
  • skin allergic reactions
  • anaphylactic reaction
  • purpura
  • severe allergic vasculitis
  • erythema multiforme
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a closed container that protects it from light, and the temperature should be kept below 30 degrees Celsius. Storing it in this manner will help maintain the drug's efficacy and prevent deterioration.

Appearance and packaging

Appearance

Brown oval soft capsule

Package unit

30 capsules (10 capsules/PTP x 3)

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.