Glipiron 2 mg (Glymepiride)

Adult dose

Dosage is individually adjusted for each patient. It should be swallowed without chewing, with more than 1/2 cup of water. Administered orally once daily, ideally before breakfast or immediately before the first meal. It is crucial not to skip meals after taking the medication. Initial dosage for monotherapy: Start at 1 mg per day of glymepiride. If necessary, the dosage can be increased by 1 mg after intervals of 1 to 2 weeks. Generally, when 4 mg or more is administered, additional effects are minimal; however, some patients show better metabolic control with doses up to 6 mg (or 8 mg). If 4 mg per day fails, consider switching to insulin therapy, or if not, consider combination therapy with insulin or other oral diabetes medications. 2) Secondary dosage adjustments As treatment progresses, the need for this medication may decrease with improved diabetes control. Therefore, dosage reduction or discontinuation of this medication may be necessary to avoid hypoglycemia. Dosage adjustments should also be considered if weight loss, lifestyle changes, or other factors that increase risk of hypoglycemia or hyperglycemia arise.

This medication should not be used in patients with type 1 diabetes or those with diabetic ketoacidosis or coma. Additionally, individuals allergic to this medication or to sulfonylureas and sulfonamides should not take it. In patients with severely impaired liver or kidney function, switching to insulin therapy is recommended instead of using this medication. Pregnant women or those who may become pregnant, as well as breastfeeding women, should refrain from taking this medication. Patients with severe infections, those undergoing surgery, or those who have sustained significant injuries are safer undergoing insulin therapy. In cases of gastrointestinal disturbances such as diarrhea or vomiting, care should be taken due to the risk of hypoglycemia resulting from improper food absorption. This medication contains lactose, hence individuals with lactose intolerance or certain genetic metabolic disorders should not take it. During the first week of taking the medication, the risk of hypoglycemia is increased, so blood sugar levels should be monitored closely. Especially elderly individuals, those with poor nutritional status or irregular eating habits, and those who do not align their physical activity with food intake should exercise greater caution. Patients who frequently consume alcohol or have diminished liver and kidney function are also at higher risk for hypoglycemia. Caution should be taken in cases with other endocrine diseases, overdose of this medication, or concurrent use of various medications. This medication contains Yellow No. 4 dye, and those allergic to this ingredient should use it cautiously. Hypoglycemia may occur, with symptoms including headache, severe hunger, nausea, fatigue, confusion, drowsiness, and decreased consciousness. If these symptoms occur, it is crucial to immediately consume sugar or seek medical assistance. Temporary blurred vision, gastrointestinal disorders, liver function abnormalities, blood disorders, and allergic reactions have also been reported. While taking this medication, maintaining regular meals, exercise, and weight management is important, and frequent monitoring of blood sugar levels is necessary. It is essential to be well-informed about the symptoms of hypoglycemia and to always carry sugar. When receiving treatment at another hospital, it is imperative to inform them about your diabetes status and medication history. In stressful situations such as infections, surgery, or trauma, transitioning to insulin therapy may be necessary. This medication is excreted via the kidneys, so elderly patients should adjust the dosage according to kidney function. In the case of overdose, severe hypoglycemia may occur, requiring immediate treatment at a medical facility, and inducing vomiting or gastric lavage may be necessary. This medication has not been proven safe or effective in children, and thus should not be used in pediatric patients. Taking this medication alongside other drugs may affect blood sugar control; therefore, it is essential to consult with healthcare providers. Finally, pregnant or breastfeeding women should ideally avoid this medication and consider switching to insulin therapy.

Serious side effects

Hives, severe swelling (edema), difficulty in breathing, shock, hypotension, skin and mucous membrane syndrome (Stevens-Johnson syndrome), jaundice, liver dysfunction, hepatitis, liver failure, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia, thrombocytopenic purpura, anaphylaxis

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility or activity

This medication is sensitive to air and moisture, so it should be stored in a sealed container. It is important to maintain the storage temperature between 1 degree Celsius and 30 degrees Celsius at room temperature. This will help preserve the efficacy of the medication for a longer duration.

Appearance

Green, oblong tablet

Package unit

30 tablets/bottle, 200 tablets/bottle