Hirumax Injection (Pre-filled) (Sodium Hyaluronate)

Adult administration

Typically, adults receive one injection per week, administering one tube continuously for 3 weeks into the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or bicipital tendon sheath), but the frequency of administration should be adjusted according to symptoms. As this medication is administered into the joint, it must be performed under strict aseptic techniques.

This medicine should not be used in patients who have had an allergic reaction to any of its components. Furthermore, it should be used cautiously in patients who have had allergic reactions to other drugs, those with liver function issues, or patients with a history of liver disease, as liver function test results may be abnormal in those with a history of liver disease. As this medication is injected into the joint, caution is required if there are skin conditions or infections at the injection site. Though rare, serious allergic reactions such as shock may occur during use, so if symptoms appear, administration must be stopped immediately and appropriate treatment sought. Additionally, allergic symptoms such as facial or eyelid swelling, rashes, and itching may occur, so administration should be halted if these symptoms present. Transient pain, swelling, redness, warmth, or a feeling of pressure may occur at the injection site, and symptoms like nausea, vomiting, or fever may also manifest. For patients with severe inflammatory osteoarthritis of the knee, it is advisable to use this medication after the inflammation has subsided. Post-administration, measures to stabilize the joint area are recommended. If the medication leaks outside the joint, pain may occur, so it must be injected precisely into the joint. Injections should be performed in a sterile environment, and if symptoms do not improve, administration should be limited to a maximum of three times. If there is an excess of joint fluid, it is advisable to drain it before injection. This medication should not be used for intravenous injection or for ophthalmic use, and it is safe to use a syringe needle of approximately 22-23 gauge. Caution should be exercised as precipitation may occur if used with disinfectants such as Benzalkonium chloride or Chlorhexidine. For women who are pregnant or may become pregnant, the safety of this medication is not well established, so it should be used cautiously only when the benefits of treatment outweigh the risks. Additionally, this medication may be passed into breast milk, so breastfeeding should be avoided during administration. The safety for pediatric use has not been sufficiently confirmed, and it should be used cautiously only when absolutely necessary. Elderly patients may have decreased body function, so careful attention is needed when using this medication.

Serious side effects

Shock symptoms

Mild side effects

• Facial swelling
• facial redness
• rash
• hives
• itching
• pain
• swelling
• edema
• redness
• warmth

This medicine should be stored in a sealed container to prevent air or moisture ingress. It is important to maintain the storage temperature between 1 and 30 degrees Celsius to ensure the medicine's effectiveness and safe use.

Appearance

A colorless, transparent, viscous liquid filled in a colorless, transparent glass syringe closed on both ends by rubber stoppers, part of the pre-filled syringe system.

Package unit

2mL/tube X 3