Glyrile Tablets (Glimepiride)

Adult dose

For patients who have not previously been treated with medications, the starting dose is 1 mg of glimepiride once daily. If necessary, the dosage can be increased by 1 mg at intervals of 1 to 2 weeks. Generally, additional effects are limited when doses of over 4 mg are administered, but some patients have shown better metabolic control with an increase up to 6 mg (or 8 mg). If the 4 mg daily dose fails,

This drug should not be used in patients with insulin-dependent diabetes mellitus, diabetic ketoacidosis, or diabetic coma. It should not be administered if there is an allergy to this drug, its components, or sulfonylurea derivatives. Because there is limited experience in patients with severe liver or kidney impairment, switching to insulin therapy is recommended. It is safe to avoid this medication in pregnant women or those who may become pregnant, as well as in nursing mothers. Insulin therapy is recommended for patients with severe infections or before and after surgery and severe trauma, and caution should be exercised in patients with gastrointestinal disorders as there is a risk of hypoglycemia when taking this medication. During the first week of taking this medication, there is a heightened risk of hypoglycemia, so blood glucose levels should be monitored closely. Special caution is required for the elderly, malnourished patients, those with irregular eating patterns, inconsistent exercise and carbohydrate intake, and changes in eating patterns. Patients who frequently consume alcohol, or have decreased kidney and liver function, as well as those with other endocrine disorders, are at higher risk for hypoglycemia and require careful monitoring. Furthermore, if this medication is taken in excessive amounts or in combination with other drugs, the risk of blood sugar fluctuations exists, and consultation with a physician is necessary. This medication lowers blood sugar levels and can cause hypoglycemia, with symptoms including headache, severe hunger, nausea, fatigue, anxiety, confusion, drowsiness, and loss of consciousness. Severe hypoglycemia may lead to seizures or coma, so if symptoms occur, immediate intake of sugar or seeking medical help is required. Additionally, initial administration may lead to temporary visual disturbances, gastrointestinal symptoms, liver dysfunction, blood abnormalities, allergic reactions, etc., so caution is advised. If severe allergic reactions occur, patient should stop taking the medication immediately and inform the healthcare provider. It is important to take this medication regularly along with dietary and exercise regimens and frequently check the blood glucose control status. In case of hypoglycemia, consuming sugar or sugar-containing beverages quickly can relieve symptoms, so it is advisable to always carry sugar with you. Under special circumstances such as stress, surgery, or infection, controlling blood glucose levels may become difficult, so consultation with healthcare professionals is necessary. Also, this medication may affect the ability to drive or operate machinery, so caution is advised. This medication is metabolized in the liver, which may cause interactions with certain other medications. Especially, taking this drug with specific antibiotics, antifungals, anticoagulants, etc., may affect blood glucose control; therefore, patients should inform the healthcare provider of any medications currently being taken. If used with beta-blockers or certain sympatholytics, symptoms of hypoglycemia may be masked, necessitating even more caution. Pregnant women and nursing mothers should receive insulin therapy instead of this medication, as it may affect the fetus or newborn. Safety and efficacy in children and adolescents under 18 years have not been established, so use is not recommended. The elderly may have decreased kidney function, so particular attention should be given to dose adjustment and blood glucose monitoring while taking this medication. In case of overdose, severe hypoglycemia may occur, requiring immediate visit to a medical institution for appropriate treatment. In emergencies, intravenous glucose may be needed to quickly normalize blood sugar levels, followed by continuous monitoring.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, yellowing of the skin or eyes (jaundice), severe lethargy throughout the body, thrombocytopenia with a platelet count below 10,000/μL and thrombocytopenic purpura, severe swelling associated with hypertension, anaphylaxis, angioedema, Stevens-Johnson syndrome.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility or activity

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature.

Appearance

Dark blue rectangular tablets

Package unit

30 tablets/bottle, 300 tablets/bottle