Cradus Syrup (Amoxicillin Trihydrate & Clavulanate Potassium (7:1))

Adult dose

For recurrent tonsillitis and other upper respiratory infections, lower respiratory infections, urinary infections, and skin and soft tissue infections, the dosage of Amoxicillin/Clavulanate Potassium is typically 25 mg/3.6 mg per kg of body weight per day divided into two doses. For severe infections such as otitis media, sinusitis, and bronchopneumonia, the dosage is 45 mg/6.4 mg per kg of body weight per day.

Child dose

The 7:1 syrup is not suitable for children under 2 months of age. It is not suitable for pediatric patients with renal failure.

This medication is a beta-lactam antibiotic and should not be administered to patients with allergies to penicillins or cephalosporins. Care should be taken to avoid use in patients with a history of severe hypersensitivity reactions such as anaphylaxis, Stevens-Johnson syndrome, or shock. There is an increased risk of rash in patients with infectious mononucleosis or lymphocytic leukemia. Patients with a history of jaundice or liver dysfunction from this medication or penicillins should avoid it due to the risk of recurrence. This medication contains lactose, so it should not be used in patients with lactose intolerance or related genetic disorders. Patients with impaired liver function should be administered the drug with caution as it may worsen liver function. Those with severe kidney disease may need to extend the interval between doses due to prolonged drug retention. Patients with allergies or bronchial asthma, and skin rashes are at risk for adverse reactions and should be monitored. For patients who cannot take oral medications, elderly patients, or those in poor overall condition, monitoring for symptoms of vitamin K deficiency may be necessary. Patients with gastrointestinal diseases may experience insufficient drug absorption in cases of severe vomiting or diarrhea. This medication may cause gastrointestinal side effects such as diarrhea, vomiting, and abdominal pain, and should be discontinued immediately if severe gastrointestinal disturbance occurs. Liver function abnormalities may occur rarely; therefore, regular liver function tests should be done during long-term use. Serious skin reactions such as rashes, urticaria, or in severe cases, Stevens-Johnson syndrome may occur, and the medication should be discontinued immediately upon symptom onset. Blood-related abnormalities such as a decrease in blood cell counts or anemia have also been reported, so testing is necessary if any unusual symptoms occur. Central nervous system symptoms such as drowsiness, insomnia, or seizures may rarely occur, and any signs of abnormalities should be reported to a doctor. Impaired kidney function may lead to acute kidney failure or nephritis, thus regular kidney function tests are necessary. Antibiotic use can disrupt intestinal bacterial balance, leading to candida infections or stomatitis, so vigilance is necessary if symptoms occur. Prolonged administration may lead to a risk of bleeding due to vitamin K deficiency; if bleeding symptoms arise, immediate consultation with medical personnel is necessary. Avoid administering this medication during the first three months of pregnancy, and caution should be exercised during breastfeeding as adverse effects may occur in infants. Safety in premature infants or neonates has not been established, so use should be approached carefully. Elderly patients may experience adverse reactions more easily due to declines in kidney and liver function, thus dosage and interval should be adjusted and monitored. This medication may interact with other drugs, so inform medical personnel of any concurrent medications. In case of overdose, gastrointestinal symptoms, kidney function abnormalities, and central nervous system disturbances may occur, thus immediate medical attention is necessary. The medication should be stored refrigerated after preparation and used within 7 days, and it must be shaken well before use.

Serious side effects

Urticaria, severe swelling (including angioedema), chest tightness, difficulty breathing, cold sweat, pallor, anaphylaxis, mucocutaneous syndrome (Stevens-Johnson syndrome), shock, severe skin reactions, serum sickness, vasculitis, acute generalized exanthematous pustulosis, bronchospasm, laryngeal edema, anaphylactic shock, hypotensive symptoms, hepatitis, cholestatic jaundice, liver abnormalities (jaundice), sudden severe headache, seizures, loss of consciousness

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, abdominal bloating, constipation, colicky pain, gastric acidity, loose stools, dry mouth, acute pancreatitis, candidiasis, antibiotic-associated colitis, bloody stools, itching, erythema multiforme, dermatitis, acute generalized exanthematous pustulosis, thrombocytopenia, anemia, thrombocytopenic purpura, eosinophilia, leukemia, lymphopenia, mild thrombocytosis, bone

This medication can be sensitive to air and moisture, hence it should be stored in a tightly closed container. It is also important to store it in a cool, dry place below 25 degrees Celsius to maintain its efficacy.

Appearance

White or pale yellow powder that is mixed with water to prepare the syrup.

Package unit

50mL / bottle