Clopidogrel 75 mg (Clopidogrel Bisulfate)

Adult dose

1. For patients with ischemic stroke, myocardial infarction, or peripheral artery disease, administer clopidogrel at a dosage of 75 mg orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-ST elevation myocardial infarction), start with a loading dose of 300 mg orally on the day of medication initiation, followed by a maintenance dose of 75 mg orally once daily. At this time, aspirin 75 – 325 mg should be given in combination with this medication once daily. 3. For patients with atrial fibrillation, administer 75 mg orally once daily of this medication. At this time, aspirin 75 – 100 mg should also be taken in combination with this medication once daily. ○ Renal impairment patients: Treatment experience in patients with renal disorders is limited. ○ Liver impairment patients: Treatment experience in patients with moderate liver disease with bleeding diathesis is limited. This medication can be taken regardless of food intake.

This medication helps prevent platelets from aggregating, allowing blood to flow more easily. Certain genetic factors may cause the drug to not work effectively in patients taking this medication, and genetic testing may need to be considered for alternative treatment options. Additionally, taking this medication with certain drugs that activate specific enzymes may increase the risk of bleeding, so combination with such medications is not recommended. This drug should not be administered to patients with a history of hypersensitivity or bleeding, severe liver impairment, breastfeeding women, and certain genetic lactose intolerance patients. Patients with a high risk of bleeding or those scheduled for surgery should exercise caution when using this medication and may need to discontinue the medication 5-7 days prior to surgery if necessary. This medication may increase the risk of bleeding when used in combination with other bleeding risk medications, necessitating careful monitoring during concurrent use. If any bleeding symptoms occur while taking this medication, notify your healthcare provider immediately and have your condition checked through blood tests, etc. Rarely, this medication may cause a serious blood disorder called Thrombotic Thrombocytopenic Purpura (TTP), requiring immediate treatment if related symptoms appear. Possible side effects include bleeding, gastrointestinal symptoms, headache, dizziness, skin rash, etc. Immediate medical attention is necessary for any serious adverse reactions. Use during pregnancy should be carefully considered for potential effects on the fetus, while breastfeeding mothers should determine whether to discontinue breastfeeding, given the possibility of the drug being excreted into breast milk. Elderly patients or those with decreased renal and liver function may have an increased risk of bleeding, thus requiring dosage adjustments and monitoring. In the event of overdose, bleeding time may be prolonged, and due to the lack of a specific antidote, platelet transfusion may be necessary to halt bleeding. Keep this medication out of reach of children, and avoid transferring it to other containers.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in mouth/eye mucosa, shortness of breath or difficulty in breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), severe malaise, sudden and very severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Headache
• dizziness
• abdominal pain
• dyspepsia
• diarrhea
• nausea
• rash
• pruritus
• fatigue
• lower back pain

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is recommended to maintain storage temperatures between 1 to 30 degrees Celsius (room temperature). This way, the effectiveness of the medication can be preserved safely for a long time.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle