Vitamin D3 Bion (Cholecalciferol)

Adult administration

Use as prescribed by a physician, adjusting the dosage based on the blood levels of 25-hydroxy vitamin D. Adults are administered 200,000 IU of cholecalciferol via intramuscular injection. Elderly individuals are administered 100,000 IU of cholecalciferol via intramuscular injection. Ensure the annual dosage does not exceed 600,000 IU of cholecalciferol.

Child administration

Adolescents are administered 200,000 IU of cholecalciferol via intramuscular injection.

Since this medication contains vitamin D, the total intake must be checked when taken with vitamin D fortified foods or other vitamin D preparations. Regular monitoring of calcium levels in blood and urine must be conducted, and the administration should be discontinued immediately if exceeding the normal range. It is especially important to frequently monitor calcium levels in the blood and urine if calcium intake is high. This medication should not be used in patients with certain diseases or impaired renal function, as well as in pregnant or breastfeeding women. Various side effects such as headaches, fatigue, muscle pain, digestive disorders, dehydration, hypertension, and kidney issues may occur, so any abnormal symptoms should be immediately discussed with healthcare professionals. Injection sites may develop inflammation or rashes, so it is essential to keep the injection site clean and monitor closely. When administered to patients with vitamin D deficiency, serum vitamin D levels should be regularly checked to prevent overdosing. In particular, elderly patients or those taking specific medications should undergo regular renal function tests and dosage adjustments if necessary. There may be interactions with certain medications, thus it is crucial to inform healthcare providers about any other medications being taken. During pregnancy, the use of this medication should be avoided as there is a risk of fetal abnormalities due to hypercalcemia. The safety and efficacy in children under 12 years of age have not been established; hence, usage is not recommended. In case of overdose, administration should be immediately discontinued, calcium intake reduced, and hydration maintained to regulate body calcium levels through diuresis. This medication should not be mixed with other drugs and should be used quickly after opening; any remaining medication should be discarded. For storage, it is safe to keep it in a sealed container to avoid exposure to air or light, away from direct sunlight at a temperature range of 1 to 25 degrees Celsius. This helps maintain the efficacy and prevent degradation of the medication.

Serious side effects

Kidney disorders, abnormalities in blood and urinary calcium levels due to hypercalcemia, severe edema, arrhythmias, severe allergic reactions (including hives at the injection site)

Mild side effects

Headaches, weakness, fatigue, muscle pain, loss of appetite, weight loss, growth retardation, nausea, vomiting, constipation, diarrhea, polydipsia, polyuria, dehydration, hypertension, calcium stones, calcification of tissues such as kidneys and blood vessels, excessive bone calcification, arrhythmias, psychological symptoms, sensory disturbances, joint pain, myasthenia, drowsiness, azotemia, hypersensitivity reactions, thirst, confusion, bloating, abdominal pain, metallic taste, dry mouth, rash, itching, hypercalciuria, hypercalcemia

This medication must be stored in a sealed container to prevent exposure to air or light, kept in a cool place away from direct sunlight at a temperature range of 1 to 25 degrees Celsius. By doing so, the efficacy is maintained and degradation is prevented.

Appearance

Colorless transparent ampoule containing odorless, pale yellow transparent injection solution

Package unit

1 ampoule (1 mL/ampoule)