Ibandronate Sodium 150 mg (Ibandronic Acid Sodium Hydrate) Tablet

Adult dose

Once a month, take 1 tablet regularly each month on the same day in the morning with a sufficient amount of water at least 1 hour before consuming food, beverages (excluding water), or other oral medications or dietary supplements (including calcium). This medication should be swallowed in an upright position or sitting down with a sufficient amount (180-240 mL) of water, and do not lie down for 60 minutes after taking it. Spring water may reduce the absorption of this medication.

Child dose

The efficacy and safety in children under 18 have not been studied.

This medication should not be administered to certain patients. For example, individuals allergic to this medication or its ingredients, patients with untreated hypocalcemia, those who cannot sit or stand upright for at least 60 minutes, and patients with esophageal issues making it difficult for food to pass should not use this medication. Additionally, this medication contains lactose, so patients with lactose intolerance or genetic lactose metabolism disorders should not take it. It should be used cautiously in patients with severe renal failure, and a discussion with a physician is essential before administration. During the course of taking this medication, various side effects such as indigestion, nausea, abdominal pain, diarrhea, headache, muscle pain, joint pain, and rash may occur. Most are mild to moderate and do not require discontinuation of treatment. Rarely, serious side effects may occur, such as esophagitis, esophageal ulcers, dizziness, angioedema, and urticaria, so it is important to inform healthcare professionals immediately if any unusual symptoms arise. This medication may irritate the gastrointestinal mucosa, so caution is needed when taken by individuals with gastritis or esophageal issues. It is mandatory to sit or stand upright for at least 60 minutes after taking it, and it is advisable not to take it with food or other medications. As a bisphosphonate, it carries a risk of osteonecrosis of the jaw, so a dental examination should be conducted before dental treatments, and excessive dental work should be avoided. Additionally, severe bone, joint, and muscle pain might occur while taking this medication, and if these symptoms persist, a consultation with a physician is advised. This medication may inhibit absorption when taken with calcium, milk, iron, etc., so it is necessary to avoid consuming other foods or medications for one hour after administration. It is recommended that pregnant or breastfeeding women do not use this medication, and its safety in children or adolescents under 18 has not been established. Overdosage may lead to gastrointestinal disturbances or hypocalcemia, so the dosage must be strictly adhered to, and in case of overdose, do not induce vomiting, and seek medical attention immediately. This medication should be kept out of the reach of children, and expired medications should be disposed of appropriately to avoid environmental damage.

Serious side effects

• Urticaria, angioedema, facial swelling → severe allergic reactions
• Esophagitis, including esophageal ulcers or strictures, esophagitis → severe gastrointestinal abnormalities
• Uveitis, scleritis, episcleritis → inflammation of the eyes
• Stevens-Johnson syndrome, erythema multiforme, bullous dermatitis → severe skin abnormal reactions
• Anaphylactic reactions/shock → severe allergic reactions
• Exacerbation of asthma → respiratory issues
• Osteonecrosis of the jaw, external auditory canal osteonecrosis → severe swelling or

Mild side effects

• Indigestion
• nausea
• abdominal pain
• diarrhea
• bloating
• gastroesophageal reflux disease
• headache
• influenza-like illness
• fatigue
• muscle pain

This medication should be stored in a tightly sealed container to prevent contact with air or moisture. Additionally, it is best stored at a temperature between 1 and 30 degrees Celsius.

Appearance

White to almost white oblong film-coated tablets

Package unit

1 tablet/PTP