Letopra Tablet 20 mg (S- Pantoprazole Sodium Trihydrate)

Adult dose

1. Gastric ulcer and moderate-to-severe reflux esophagitis - The usual adult dose is 1 tablet once daily (equivalent to 20mg of S-pantoprazole), taken with water before breakfast. Do not chew or crush the tablet. - Healing occurs within 4 weeks in most cases, although the healing period may occasionally vary by patient. If healing is incomplete after the initial 4 weeks of treatment, continue treatment for another 4 weeks. - If the condition has not responded to other treatments, the dose may be doubled (equivalent to 40 mg of S-pantoprazole per day). 2. Duodenal ulcer - The usual adult dose is 1 tablet once daily (equivalent to 20 mg of S-pantoprazole), taken with water before breakfast. Do not chew or crush the tablet. - Healing occurs within 2 weeks in most cases, although the healing period may occasionally vary by patient. If healing is incomplete after the initial 2 weeks of treatment, continue treatment for another 2 weeks. - If the condition has not responded to other treatments, the dose may be doubled (equivalent to 40 mg of S-pantoprazole per day). ◯ For elderly patients or patients with renal impairment, do not exceed 20mg of S-pantoprazole per day. ◯ For patients with severe liver impairment, reduce the dose and take 1 tablet (equivalent to 20mg of S-pantoprazole) once every other day.

This medication should not be used in patients with moderate to severe impairment of liver or kidney function as safety and efficacy have not been fully established. Patients with a history of allergy or hypersensitivity to this medication, its ingredients, or benzimidazole derivatives should not take it. Additionally, like other proton pump inhibitors, this medication must not be used in conjunction with the antiviral agent atazanavir. Women in early pregnancy or those who may become pregnant, as well as nursing mothers, are advised not to use this medication. Patients taking rilpivirine should not use this medication in combination. Since this medication contains the dye Yellow No. 5, the use should be cautious for patients with allergies to this ingredient. While using this medication, gastrointestinal symptoms such as constipation, diarrhea, gastritis, and dyspepsia may occur, and any abnormal symptoms should be reported. Rarely, serious allergic reactions such as hives, angioedema, and anaphylaxis may occur, so caution is warranted. Long-term use may lead to malabsorption of vitamin B12; thus, regular monitoring is necessary. Moreover, this medication may increase the risk of fractures, so caution is required for long-term high-dose use concerning bone health. Prolonged use beyond 3 months may result in electrolyte disturbances such as hypomagnesemia, so checking magnesium levels through blood tests is advisable. This medication may interact with other drugs, particularly anticoagulants, methotrexate, and specific antivirals, so consulting with a physician or pharmacist is essential when taking these medications. Dizziness or visual disturbances may occur during treatment, so caution is required when driving or operating machinery. If diarrhea persists during treatment, consider the possibility of Clostridium difficile infection and inform healthcare professionals immediately. It is safest not to use this medication during pregnancy or lactation, and decisions should be made after consulting with a physician if necessary. Safety in pediatric patients has not been fully established; hence, it is a principle not to use it in children. This medication should be swallowed whole without chewing or crushing, and it should be kept out of reach of children. Long-term use of this medication may lead to the development of gastric polyps, so regular endoscopic examinations are recommended. If any adverse reactions or suspected symptoms occur, consult healthcare professionals immediately to receive appropriate care.

Anaphylaxis, anaphylactic shock, angioedema, bronchospasm, acute interstitial nephritis, hives, constipation, diarrhea, gastritis, gastric polyp, hiatal hernia, loose stools, chest pain, dyspepsia, nausea, vomiting, abdominal bloating, enteritis, edema, fatigue, fever, sweating, hypertension, tachycardia, ear and throat dysfunction, dry eyes, visual disturbances, cold, elevated liver enzymes, insomnia, dizziness, neuropathy, drowsiness, back pain, limb pain, headache, stomach ache, boils, itching, rash, nosebleed, elevated creatine phosphokinase, elevated liver enzymes (AST), decreased appetite, stomatitis, nasal congestion, runny nose, sore throat, upper respiratory infection, neutropenia, skin lacerations, abdominal pain, numbness, increased sputum, bladder residual urine, amputation, upper abdominal pain, distention, nausea, belching, dry mouth, weakness, lethargy, elevated body temperature, elevated bilirubin, liver failure, jaundice, anaphylactic shock, arthralgia, myalgia, rhabdomyolysis, bone fracture, headache, taste disturbance, sleep disorders, depression, hallucinations, confusion, disorientation, interstitial nephritis, pruritus, skin erythema, hives, angioedema, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, Riel syndrome, photosensitivity, hyperglycemia, agranulocytosis, leukopenia, thrombocytopenia, pancytopenia, gynecomastia, hyperlipidemia, lipid increase, weight change, hyponatremia, hypomagnesemia, elevated CK, anxiety, bronchitis, increased cough, respiratory distress, flu-like symptoms, gastroenteritis, gastrointestinal disorders, tension, infection, migraine, cervical pain, pain, pharyngitis, rectal disorders, rhinitis, elevated AST, sinusitis, upper respiratory infection, frequent urination, urinary tract infection, boils, allergic reactions, chills, abscess, facial edema, general edema, flush, hernia, abnormal clinical laboratory tests, lethargy, moniliasis, tumors, nonspecific drug reactions, electrocardiogram abnormalities, angina, arrhythmia, atrial fibrillation, coronary artery disease, congestive heart failure, bleeding, hypotension, myocardial infarction, myocardial ischemia, palpitations, retinal vascular disease, syncope, thrombophlebitis, thrombosis, vasodilation, decreased appetite, aphthous stomatitis, colitis, duodenitis, swallowing difficulty, esophageal bleeding, esophagitis, gastric-duodenal tumor, gastric-duodenal bleeding, gastric-duodenal moniliasis, gingivitis, halitosis, hematemesis, increased appetite, melena, oral ulcers, oral moniliasis, periodontal abscess, periodontitis, rectal bleeding, gastric ulcer, bowel disorders, tongue discoloration, ulcerative colitis, diabetes, goiter, biliary colic, hyperbilirubinemia, cholecystitis, cholelithiasis, jaundice, hepatitis, elevated ALP, anemia, petechiae, eosinophilia, iron deficiency anemia, leukocytosis, thrombocytopenia, dehydration, gout, thirst, weight gain, weight loss, arthritis, bone disease, joint disease, leg cramps, bursitis, tendinitis, abnormal dreams, confusion, seizures, dry mouth, aphasia, hyperactivity, decreased libido, anxiety, neuralgia, neuritis, neurological disorders, abnormal sensation, diminished reflexes, abnormal perception, tremors, asthma, hiccups, laryngitis, respiratory disorders, pneumonia, voice alteration, acne, alopecia, contact dermatitis, eczema, fungal dermatitis, bleeding, herpes simplex, shingles, lichen planus dermatitis, papulosquamous rash, skin diseases, skin ulcers, sweating, amblyopia, cataracts, hearing loss, diplopia, otalgia, paralysis, glaucoma, otitis externa, taste disturbance, tinnitus, albuminuria, balanitis, mastalgia, cystitis, menstrual irregularities, dysuria, epididymitis, hematuria, erectile dysfunction, renal stones, renal pain, nocturia, prostate disorders, pyelonephritis, scrotal swelling, urethral pain, urethral disease, urinary disorders, vaginitis, Clostridium difficile-associated diarrhea, DRESS syndrome, systemic lupus erythematosus, cutaneous lupus erythematosus, gastric polyp

This medication is sensitive to light, so it should be stored in a tightly sealed container that is protected from light. It is important to maintain a storage temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the medication's efficacy and safety.

Appearance

Yellow, enteric-coated, double convex oval-shaped tablets

Package unit

28 tablets/bottle, 28 tablets/box [(7 tablets/Alu-Alu X 4)]