Laxem Tablets 2/500 mg

Adult dose

This medication is administered 1-2 times a day just before or with meals. Treatment typically starts at a low dose and can be adjusted based on the patient's current medications and blood sugar levels. The initial daily dosage in clinical trials was glimepiride/metformin hydrochloride 2mg/500mg, with experience of gradually increasing up to 8mg/2000mg based on blood sugar monitoring results. Single-agent glimepiride is generally administered at doses above 4mg daily, with little additional effect; however, some patients have shown better metabolic control by increasing to 6mg (or 8mg). When used as alternative therapy in combination therapy, dosage and administration should be based on current co-administered glimepiride and metformin hydrochloride regimens. If a previous dose is missed, do not exceed the single dose at the next administration.

This medication is primarily used for patients with type 2 diabetes to help control blood sugar levels. Renal function is very important while taking this medication. Impaired renal function can lead to drug accumulation in the body, which can result in dangerous lactic acidosis, thus regular kidney function tests should be conducted. If symptoms such as dehydration, severe diarrhea, vomiting, or fever occur, discontinuation of medication should be considered and medical advice should be sought. Patients at risk of cardiovascular diseases should discuss thoroughly with their doctor before taking this medication, and should be well aware of the symptoms of hypoglycemia, as there is a risk of low blood sugar. Women who are pregnant or may become pregnant, as well as nursing mothers, are advised not to take this medication, and if planning to become pregnant, consultation with a doctor is necessary. This medication should not be administered to individuals with specific liver dysfunction, severe renal impairment, acute metabolic acidosis, or certain hereditary lactose metabolism disorders. Regular meals and exercise should be maintained during medication, and blood sugar and renal function should be monitored regularly to confirm the efficacy and safety of the medication. Symptoms of hypoglycemia may include headaches, dizziness, tremors, and cold sweats, so if these symptoms occur, immediate intake of sugar is recommended and medical personnel should be informed if necessary. Consumption of alcohol may increase the risk of side effects from this medication, so it is important not to overconsume alcohol while taking it. Other medications taken concurrently may affect blood sugar control, so it is essential to inform healthcare providers of any other medications being used. In the case of overdose, serious hypoglycemia or lactic acidosis may occur, so do not change the dosage without a doctor’s instructions, and seek medical attention immediately if unusual symptoms arise. Special care is needed for children and the elderly, particularly as elderly individuals frequently experience decreased renal function, making dosage adjustments and monitoring essential. While taking this medication, side effects may include dyspepsia, nausea, diarrhea, skin rash, etc., and if a severe allergic reaction is suspected, medical personnel should be informed immediately. Finally, this medication should be stored out of the reach of children and should not be transferred to another container.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, chest tightness, cold sweats, pallor, severe allergic reactions. Severe rashes with high fever, blisters, peeling skin, oral/ocular mucosal pain, severe skin adverse reactions. Shortness of breath or difficulty breathing, asthma attacks, cough with fever accompanying respiratory issues. Yellowing of the skin or eyes (jaundice), extreme lethargy, liver anomalies (jaundice). Sudden and severe headaches.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain), unpleasant metallic taste, visual impairment, taste disorders, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia, vitamin B12 deficiency, increased liver enzymes, liver function impairment, hepatitis, allergic vasculitis, photoallergy, decreased serum sodium concentration, hypothyroidism

This medication should be stored in a sealed container to prevent air entry, at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain its efficacy and prevent degradation.

Appearance

White elongated film-coated tablets

Package unit

30 tablets/bottle, 200 tablets/bottle, 300 tablets/bottle