Creon Capsule 40000 (Pancreas Powder)

Adult dose

The dose always depends on the severity of pancreatic impairment and the composition of the meal. Adults and adolescents aged 12 years and older The recommended dose is 20,000 ∼ 40,000 EP units of lipase activity from pancreatin powder per meal. Depending on the degree of indigestion, the required amount may be considerably higher. In particular, in patients with cystic fibrosis, the dose of enzymes required for adequate fat absorption should not be exceeded, and the amount and composition of meals should be taken into account. The dose should be increased cautiously and in association with improvement in symptoms (e.g., steatorrhea, abdominal pain). Do not exceed 15,000 ∼ 20,000 EP units of lipase activity per kg of body weight per day or 4,000 EP units per g of fat intake. Take this drug with plenty of water during or immediately after a meal. Chewing this drug or opening the capsule may reduce its efficacy, and the release of enzymes in the mouth may damage the oral mucosa. Therefore, swallow this drug whole. If swallowing the capsule intact is difficult (e.g., for children or older adults), open the capsule, mix its contents with a liquid or soft food (pH < 5.5), and take immediately. The contents must be swallowed immediately without chewing. The duration of treatment depends on the severity of the disease.

Child dose

Children aged 4 years and under 12 years: Start with a weight-based dose of 500 EP units of lipase activity from pancreatin powder per kg of body weight per meal.

This medication should not be taken by individuals who are allergic to beef or pork or have had hypersensitivity reactions to this medication or its components. Patients with acute pancreatitis or those with chronic pancreatitis that has presented acutely should not take this medication. While taking the medication, do not chew the capsule; exposure of the contents in the mouth can cause damage to the oral mucosa. Those taking other medications must consult a doctor or pharmacist before taking this medication. Cystic fibrosis patients need to be cautious as this medication may cause symptoms of intestinal obstruction. Women who are pregnant or may become pregnant should take this medication only if necessary, as the effects on the fetus are not well established. Nursing mothers should avoid taking this medication unless absolutely necessary, as it may pass into breast milk. Those with a history of gout, kidney failure, or hyperuricemia should be cautious, as this medication may raise blood uric acid levels. Individuals allergic to proteins derived from pigs may experience serious allergic reactions, so they should consult a doctor before use. Those taking folate supplements should be aware that this medication may interfere with folate absorption, thus the need to monitor folate levels. Diabetics taking Acarbose or Miglitol should manage their blood sugar carefully as this medication may reduce their blood sugar control effectiveness. If abdominal pain, nausea, constipation, diarrhea, or skin rashes and allergy symptoms occur while taking this medication, discontinue use immediately and consult a professional. Particularly, cystic fibrosis patients should monitor for changes in symptoms as high doses may lead to intestinal anomalies. This medication is made from ingredients extracted from the pancreas of pigs, thus the risk of viral infection is very low but cannot be entirely eliminated, requiring caution. Fine powder entering the respiratory tract can induce asthma, so avoid inhalation while taking this medication. Store out of reach of children, and keep in the original container away from direct sunlight and moisture in a cool place.

abdominal pain, nausea, vomiting, constipation, diarrhea, abdominal distension, abnormal bowel movements, skin allergies or hypersensitivity reactions, skin rash, sneezing, tearing, bronchospasm, skin itching, hives, anaphylactic reaction, hyperuricemia, gout, fibrosing colonopathy, colitis, terminal intestinal obstruction syndrome, recurrence of existing cancer, oral and perianal ulcers, asthma, rash

Drug interactions

This medication should be taken in consultation with a doctor or pharmacist if used alongside folate preparations, Acarbose, or Miglitol.

This medication should be stored in a tightly sealed container to prevent air or moisture ingress, ideally at a cool temperature below 25 degrees Celsius. This ensures that the efficacy of the medication is maintained for a longer period.

Appearance

A hard capsule with a brown opaque upper part and a colorless transparent lower part, containing enteric-coated microtablets.

Package unit

100 capsules/bottle