Combiglyze XR 5/500 mg

Adult dose

This medication is generally administered once daily with the evening meal. - For patients not being treated with Metformin who require Saxagliptin 5mg, administer Saxagliptin 5mg/Metformin 500mg extended-release once daily. - Patients on Metformin should take Saxagliptin 5mg once daily, along with an appropriate dose of Metformin that was previously taken. - Saxagliptin in combination with

This medication can cause a very rare but potentially fatal metabolic complication called lactic acidosis, so caution is necessary. Patients with moderate to severe renal impairment, cardiovascular disease, acute infections, or severe trauma should not use this medication. It should not be administered to patients with allergic reactions to this drug or those with metabolic acidosis such as lactic acidosis or diabetic ketoacidosis. Before and after tests involving radiologic contrast agents, the administration of this medication should be temporarily suspended and should only be resumed after renal function is confirmed to be normal. It is also safer not to use this medication for pregnant or nursing women and patients with compromised liver function. During treatment with this medication, hypoglycemic symptoms may occur, so it is important to monitor blood sugar levels closely, especially when used together with hypoglycemic agents such as insulin or sulfonylureas. Additionally, this medication can lower vitamin B12 levels, so regular monitoring of vitamin B12 levels is recommended during prolonged use. Caution is required as excessive alcohol consumption or conditions like dehydration, vomiting, or diarrhea can increase the risk of side effects. If sudden symptoms of heart failure or cardiovascular abnormalities occur during treatment with this medication, immediate consultation with a healthcare professional is necessary. If any unusual reactions occur, such as blistering skin conditions or severe joint pain, the use of this medication should be discontinued, and consultation with a specialist is advised. Elderly patients may experience reduced kidney function and should have regular kidney function tests and dosage adjustments made. In cases of overdose, appropriate treatment should be sought immediately at a hospital, and if necessary, the drug can be removed via dialysis. Lastly, keep this medication out of the reach of children, and store it in its original container to prevent degradation of quality.

Serious side effects

Hives, severe swelling (edema), anaphylaxis, angioedema, severe allergic reactions, cardiovascular collapse (shock), acute myocardial infarction, sepsis, lactic acidosis, severe skin reactions (severe rashes with high fever, blisters, skin peeling, mucous membrane pain), difficulty breathing, asthma attacks, shortness of breath, jaundice, liver abnormalities, sudden and severe headaches, thunderclap headaches, seizures, altered consciousness, vision changes, paralysis, severe low

Mild side effects

• Headache
• upper respiratory tract infection
• urinary tract infection
• sinusitis
• abdominal pain
• gastroenteritis
• nausea
• diarrhea
• vomiting
• neuropathy

This medication should be stored in a tightly closed container to avoid exposure to air or moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

Pale brown and brown, double convex, film-coated tablet

Package unit

28 tablets (7 tablets × 4)/box