Plavix Tablets (Clopidogrel Sulfate)

Adult dose

1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer clopidogrel orally at a dose of 75 mg once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q wave myocardial infarction), initiate the therapy with a loading dose of 300 mg on the first day, then maintain with 75 mg orally once daily. At this time, aspirin 75 mg should be co-administered.

This medication helps blood flow by preventing platelets in the blood from clumping together. It may not be effective enough in individuals with reduced function of a specific enzyme (CYP2C19) due to genetic factors. In such cases, alternative treatments should be considered. Additionally, concomitant use of medications that activate certain enzymes may increase the risk of bleeding, so such combinations should be avoided. This medication should not be used in patients with bleeding, severe liver damage, breastfeeding women, or those with specific genetic disorders. During administration, there is a risk of bleeding, so if bleeding symptoms are suspected, medical personnel should be informed immediately. The use of this medication may need to be stopped in case of surgery or trauma. Caution is warranted if this medication is used alongside anticoagulants such as warfarin, as this increases the risk of bleeding. Moreover, it may cause side effects like gastrointestinal bleeding, skin rashes, and a reduction in blood cell counts, so if any unusual symptoms occur, consultation with a doctor should be sought immediately. While the risk to the fetus during pregnancy is not significant, caution is needed due to the bleeding risk, and consideration should be given to whether to discontinue breastfeeding since the medication may pass into breast milk. This medication is not recommended for children as safety and efficacy have not been established. For elderly patients or those with impaired kidney or liver function, there may be a higher risk of bleeding, thus dosage adjustment and careful monitoring are necessary. In case of overdose, the risk of bleeding significantly increases, requiring immediate hospital care for appropriate treatment. This medication should be stored out of reach of children and not transferred to another container for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral or ocular mucosa, feeling short of breath or difficulty breathing, asthma attacks, respiratory abnormalities associated with cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination issues.

Mild side effects

• Headache
• dizziness
• abdominal pain
• indigestion
• diarrhea
• nausea
• fatigue
• rash
• itching
• joint pain

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture. It is best to maintain a storage temperature between 1°C and 30°C.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle