Minirin Melt 240 Micrograms (Desmopressin Acetate)

Adult dose

Treatment of nocturia associated with nocturnal polyuria (adults only) Administer 60㎍ of desmopressin sublingually at bedtime. If the effect is insufficient after one week, increase the dose to 120㎍. If the effect remains insufficient, the dose may be increased at one-week intervals up to 240㎍. Fluid intake must be restricted during treatment. Discontinue treatment if there is no clinical effect within 4 weeks after dose adjustment. Initiation of treatment with this medicine is not recommended in patients aged 65 years or older. In older patients who require treatment, monitor serum sodium levels closely (see 5. General Precautions in Precautions for Use).

Child dose

Primary nocturnal enuresis (5 years and older): Administer 120㎍ of desmopressin sublingually at bedtime. If the effect is insufficient, the dose may be increased to 240㎍. Fluid intake must be restricted during treatment. If signs of fluid retention or hyponatremia occur (headache, nausea/vomiting, weight gain, and, in severe cases, seizures), discontinue treatment until the patient has completely recovered. If treatment with this medicine is to be restarted, fluid intake must be strictly restricted. Whether to continue treatment should be determined after withholding treatment for at least 1 week, 3 months after initiation.

This medication works to regulate the body's water balance and is primarily used for the treatment of enuresis. Excessive water intake can lead to low sodium levels in the body, resulting in coma or serious side effects, so one should drink only enough water to prevent thirst. Individuals with allergic reactions to this medication or those with certain heart diseases or kidney dysfunctions should not use it, and patients on diuretics should exercise caution. People with hypertension, cardiovascular diseases, chronic kidney diseases, pregnant women, children, and the elderly should be particularly careful when using this medication. During treatment, symptoms of hyponatremia and water intoxication, such as headache, nausea, weight gain, and seizures, may occur, so if these symptoms arise, immediate consultation with a healthcare professional is necessary. Water intake should be restricted one hour before taking the medication and up to eight hours afterward, and it is important to limit to within 0.5 liters for 12 hours during kidney function tests. The risk of side effects may increase when this medication is taken with certain antidepressants, diuretics, steroids, etc., so it is essential to inform the healthcare professional about any medications being taken. Women who are pregnant or may become pregnant should use this medication only after thorough review of its effects on the fetus, and those who are breastfeeding should discontinue nursing. Symptoms of overdose may include headache, nausea, seizures, and loss of consciousness, so it is crucial to seek appropriate treatment at a medical facility immediately. This medication should be kept out of the reach of children and should not be transferred to another container as it is beneficial for maintaining quality.

• Unconsciousness
• convulsions
• weight gain
• severe water intoxication
• hyponatremia
• allergic reactions
• emotional disturbances
• headache
• abdominal pain
• nausea

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is also advisable to keep it away from direct sunlight and store it at room temperature.

Appearance

White round tablet

Package unit

30 tablets (10 tablets/PTP x 3)/box