Ligarine Capsule 75 mg (Pregabalin)

Adult dose

This medication should be taken orally without regard to food in two divided doses throughout the day. 1. Neuropathic pain - Peripheral neuropathic pain: Starting dose of 150 mg once daily; after 3 to 7 days, the dose may be increased to 300 mg once daily as needed, with a maximum increase possible to 600 mg at 7-day intervals. - Central neuropathic pain: Starting dose of 150 mg once daily; after 1 week, can be increased to 300 mg once daily.

Child dose

There is insufficient safety and efficacy data for children under 12 years of age and adolescents aged 12 to 17 years; therefore, administration is not recommended.

This medication may increase the risk of suicidal thoughts or behavior; therefore, mood changes or depressive symptoms should be carefully monitored during treatment. Patients with hypersensitivity to this medication should not use it, and particular caution is required for diabetes patients as weight gain can affect blood sugar control. If allergic reactions such as angioedema occur, immediately discontinue use. Elderly patients are at risk of falls due to dizziness or drowsiness, so caution is particularly needed at the beginning of treatment. Consult a healthcare professional if visual disturbances or changes in vision occur. Sudden discontinuation of this medication may cause withdrawal symptoms such as insomnia, headache, nausea, and anxiety, so it must be tapered off gradually according to a physician's instructions. Due to the risk of drug abuse, patients with a history of substance abuse should use this medication with extra caution and be monitored for signs of misuse or dependence. Patients with impaired kidney function may need dosage adjustment, and patients with heart disease should also be cautious while taking this medication. When taken with opioid analgesics, the central nervous system depressant effect may increase, leading to respiratory depression, requiring special caution in combined use. Pregnant women should avoid using this medication in early pregnancy due to the risk of fetal malformations, and women of childbearing age should use effective contraception. Lactating women should consider discontinuing breastfeeding or the use of this medication as it is excreted in breast milk. Before performing dangerous activities like driving or operating machinery, it should be confirmed whether this medication causes dizziness or drowsiness. If skin rashes or severe allergic reactions occur, immediately stop taking the medication. In case of overdose, symptoms such as confusion, drowsiness, and depression may appear, requiring immediate hospital treatment. Keep this medication out of reach of children, and do not transfer it to other containers for safety.

Serious side effects

• Hives
• angioedema
• swelling around the face and mouth
• severe allergic reactions
• cold sweat
• Stevens-Johnson syndrome
• toxic epidermal necrolysis
• severe skin adverse reactions
• difficulty breathing
• respiratory depression

Mild side effects

• Dizziness
• drowsiness
• confusion
• disorientation
• irritability
• depression
• euphoria
• decreased libido
• insomnia
• depersonalization

This medication may be sensitive to air or moisture; therefore, it should be stored in a tightly sealed container. It is recommended to maintain the storage temperature between 15 to 30 degrees Celsius in a cool place.

Appearance

Hard capsule with a dark brown upper part and a white lower part containing a white powder

Package unit

30 capsules/bottle, 150 capsules/bottle