Glimaril M Tablet 2/500 mg

Adult dose

This medicine is administered 1 to 2 times a day before meals or with meals. The initial dosage is Glimipiride/Metformin Hydrochloride 2 mg/500 mg, and it can be gradually increased up to 8 mg/2000 mg based on blood sugar monitoring results. Single-agent Glimipiride generally does not show additional benefits when doses above 4 mg are taken daily, but it may be increased up to 6 mg or 8 mg when necessary.

This medicine may cause severe lactic acidosis or hypoglycemia; therefore, treatment should be discontinued and a doctor should be consulted if renal function declines sharply. It is advisable to temporarily stop taking this medicine if symptoms of dehydration, severe diarrhea, vomiting, or fever occur, and these symptoms should be reported to a healthcare professional. Caution is required when taking other medications, especially antihypertensives, diuretics, or non-steroidal anti-inflammatory drugs that may affect kidney function. Due to the risk of cardiovascular disease, cardiovascular health should be periodically checked during treatment with this medicine. Insulin-dependent diabetes patients or patients with acute metabolic acidosis, severe liver or kidney dysfunction, pregnant and nursing patients should not take this medicine. Particularly, patients with a kidney function less than 45 mL/min/1.73 m2 should not use this medicine, and administration should be immediately ceased if renal impairment is suspected. Patients at high risk for hypoglycemia (elderly, malnourished, irregular meals, intense exercise, alcohol consumers, etc.) require particularly careful monitoring during initial treatment and dosage adjustments. Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal pain, etc.) may occur during use, but most are temporary and can be reduced by taking it with meals. If allergic reactions or severe skin rashes, dyspnea, etc. occur, notify a physician immediately, and regular blood tests are necessary as blood abnormalities (thrombocytopenia, anemia, etc.) may occur. Vitamin B12 deficiency may occur; therefore, check serum vitamin B12 levels during long-term treatment and consider supplementation if necessary. This medication may interact with other drugs, so inform healthcare professionals of any other medications being taken, especially when combined with drugs affecting kidney function. Women who are pregnant or planning to become pregnant should not use this, and nursing mothers are also advised to avoid it. Special attention is needed when prescribing this medicine to children and the elderly, and elderly patients should undergo frequent renal function tests. In case of overdose, severe hypoglycemia or lactic acidosis may occur; thus, if suspected, visit a medical institution immediately for appropriate treatment. During treatment with this medicine, blood sugar, kidney function, and regular blood tests should be monitored to observe treatment effectiveness and side effects, and caution should be exercised regarding the risk of hypoglycemia while driving or operating machinery. Lastly, this medicine should be kept out of the reach of children and should not be transferred to other containers.

Serious side effects

Hives, severe swelling, tightness in the chest, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rashes with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, liver abnormalities, sudden and severe headache, lightning-like pain.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, anorexia, indigestion, constipation, abdominal pain), metallic taste discomfort, visual impairment, nausea, upper abdominal discomfort, abdominal pain, diarrhea, taste disturbance, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia, peripheral neuropathy due to vitamin B12 deficiency, increased liver enzymes, hepatitis, liver function impairment, vasculitis, skin photosensitivity.

This medicine should be stored in a tightly sealed container to prevent air from entering, and it is advisable to keep it at room temperature between 1 to 30 degrees Celsius. By storing it this way, the efficacy of the medicine can be well maintained.

Appearance

White oblong film-coated tablet

Package unit

30 tablets (10 tablets/PTPX3)