Neomaryl M Tablet 1/250 mg

Adult dose

This medication is administered 1 to 2 times a day before or with meals. Treatment typically starts with a low dose, and the dosage is adjusted based on the patient's current medications and blood glucose levels. In clinical trials, the initial daily dose was glymepiride/metformin hydrochloride 2 mg/500 mg, and it has been gradually increased to 8 mg/2000 mg based on blood glucose monitoring results. General use of single-agent glymepiride shows almost no additional effect when the daily dosage exceeds 4 mg; however, some patients have shown better metabolic control with increased dosages to 6 mg (or 8 mg). When used as an alternative therapy for combination treatment, it is administered based on the current usage and dosage of glymepiride and metformin hydrochloride being taken. If a previous dose is missed, do not exceed the single dose during the next administration.

This medication is an antidiabetic agent that helps lower blood sugar. However, if kidney function deteriorates rapidly, the drug may accumulate in the body, leading to a dangerous condition called lactic acidosis; therefore, it should not be administered or used with caution in patients with impaired kidney function. If dehydration or severe diarrhea, vomiting, or fever causes a lack of bodily fluids, the intake of this medication should be temporarily stopped, and a consultation with a doctor is required. In addition, patients with cardiovascular diseases or those who have previously experienced a myocardial infarction should be cautious, as the risk of cardiovascular complications may increase with this medication. It is safer for women who are pregnant or potentially pregnant, or breastfeeding, to avoid taking this medication and, if necessary, switch to insulin therapy. This medication can induce hypoglycemia, so blood sugar levels should be frequently monitored, especially during the initial period of use, and immediate action should be taken if hypoglycemic symptoms occur. Symptoms of hypoglycemia include headache, dizziness, fatigue, tremors, and severe hunger, and it is crucial to consume sugar-containing foods if these symptoms appear. Consistent meals and exercise, along with weight management, are required during the use of this medication, and regular tests of blood sugar and kidney function must be conducted. Additionally, this medication can affect blood sugar control when taken with certain medications, so inform your doctor or pharmacist if you are taking other medications. This medication may lower vitamin B12 levels, so it is advisable to check vitamin B12 levels regularly during long-term use. Any severe allergic reactions or skin rashes should be reported to a doctor immediately, and if serious adverse symptoms occur while taking this medication, cessation of the medication and consultation with healthcare professionals are required. Special care is needed when this medication is used for children, the elderly, or those with severely impaired liver function. Finally, caution is necessary when driving or operating machinery due to the risk of hypoglycemia or dizziness.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, hypotension, shock, lactic acidosis, liver function impairment (liver failure, jaundice), cardiac arrest, rectal carcinoma, seizures, confusion, paralysis, severe hypoglycemia, heart failure, cardiovascular collapse (shock), acute myocardial infarction, respiratory distress, asthma attack, severe allergic reactions, severe skin adverse reactions, severe edema, thrombocytopenic purpura, platelet count less than 10,000/μL, hepatitis.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain), metallic taste, visual impairment, taste disorder, erythema, itching, rash, palpitations, dizziness, thrombocytopenia, leukopenia, hemolytic anemia, erythropenia, agranulocytosis, pancytopenia, vitamin B12 deficiency, increased liver enzymes, hepatitis, allergic vasculitis, skin phototoxicity, serum sodium level changes.

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. It is recommended to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

White, oblong film-coated tablet

Package unit

30 tablets (10 tablets/PTP x 3)