Averin M Tablets 2/500mg (Glymeperide, Metformin Hydrochloride)

Adult dose

This medication is administered 1 to 2 times daily before meals or with meals. Treatment should begin with a low dose, and the dosage can be adjusted considering the current medications and blood sugar levels of the patient. The initial dose is Glymeperide/Metformin Hydrochloride 2mg/500mg, which can be increased up to 8mg/2000mg based on blood sugar monitoring results. In cases of alternative therapy for combination therapy, the treatment should be based on the currently concomitantly administered dosage of Glymeperide and Metformin Hydrochloride.

This medication may cause severe lactic acidosis or hypoglycemia, so caution is advised, especially in cases of rapid decline in kidney function. If there are symptoms of dehydration or if taking medications that may affect kidney function, it is advisable to temporarily discontinue this medication and consult a physician. As there may be an increased risk of death associated with cardiovascular disease, the cardiovascular condition should be closely monitored while using this medication. It should not be administered to insulin-dependent diabetes patients, patients with acute metabolic acidosis, patients with severe liver or kidney dysfunction, pregnant women, and nursing mothers. Careful monitoring is necessary from the beginning of treatment in patients or conditions with a high risk of hypoglycemia, and caution should be taken with missed meals, excessive exercise, and alcohol consumption. Gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.) may commonly occur, but they are mostly temporary and should be discussed with a physician if severe symptoms arise. Allergic reactions or hematological anomalies may occur, so any unusual symptoms should be reported to healthcare providers immediately. Regular testing of blood sugar and kidney function should be conducted to continuously monitor the effectiveness and safety of the medication, particularly in elderly patients or patients with diminished kidney function. Due to many drug interactions, it is essential to consult a physician or pharmacist when starting or stopping any new medications. It is advisable to avoid using this medication while pregnant or breastfeeding, and insulin therapy is recommended as a substitute when necessary. In cases of overdose, there is a risk of hypoglycemia or lactic acidosis, so immediate medical attention is required. Caution should be exercised as hypoglycemia or other side effects may impair attention during driving or machine operation. Special attention is needed for children and the elderly, and regular monitoring of kidney function and vitamin B12 levels should be performed.

Serious side effects

• Hives, chest tightness, difficulty breathing (severe allergic reaction)
• Severe lactic acidosis (decreased blood pH, increased plasma lactate concentration, etc.)
• Jaundice of the skin or eyes (liver dysfunction)
• Severe edema and significant decrease in urine output
• Severe neurological symptoms: severe headache, seizures, confusion, visual disturbances, paralysis
• Severe thrombocytopenia accompanied by thrombocytopenic purpura
• Increased risk of cardiovascular mortality and cardiac arrest
• Severe hypoglycemia

Mild side effects

• Gastrointestinal symptoms: diarrhea, nausea, vomiting, abdominal distension, decreased appetite, dyspepsia, constipation, abdominal pain
• Specific sensory symptoms: unpleasant taste, metallic taste, vision impairment, taste disturbance
• Skin reactions and hypersensitivity: erythema, itching, rash (mild cases)
• Hematological anomalies: thrombocytopenia, leukopenia, hemolytic anemia, erythropenia, agranulocytosis, pancytopenia
• Vitamin B12 decrease and deficiency
• Increased liver enzymes,

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is advisable to keep it at room temperature between 1 to 30 degrees Celsius. This will help maintain the medication's effectiveness for a longer time.

Appearance

White oblong film-coated tablet

Package unit

30 tablets (10 tablets PT Px 3), 100 tablets/bottle, 30 tablets/bottle