Neomaryl M Tablet 2/500 mg

Adult dose

This medication is administered 1 to 2 times a day just before or with meals. Dosage may be adjusted based on each patient's current treatment regimen, efficacy, and tolerability and should include appropriate blood sugar monitoring. Generally, treatment is initiated at a low dose, and the dosage may be adjusted considering the patient's current medications and blood sugar levels. In clinical trials, the initial dose was Glymepride/Metformin Hydrochloride 2 mg/500 mg per day, and based on blood sugar monitoring results, it can be gradually increased to Glymepride/Metformin Hydrochloride 8 mg/2000 mg. While additional effects are rarely observed when administering single-drug Glymepride above a daily dose of 4 mg, some patients have shown better metabolic control with an increase to 6 mg (or 8 mg). When using alternative therapy for combination treatment, it is administered based on the current dosage and regimen of Glymepride and Metformin Hydrochloride. If a dose is missed, do not exceed the prescribed dose at the next administration.

This medication can cause severe lactic acidosis or hypoglycemia; therefore, it should be temporarily discontinued when kidney function declines sharply or dehydration is present. Moreover, it should not be administered to patients with a kidney function below 45 mL/min/1.73 m2, those with severe liver dysfunction, or pregnant and nursing women. While this medication helps with blood sugar control, hypoglycemic symptoms may occur, so special caution is needed for the elderly, malnourished patients, or those with irregular eating habits. Initially, gastrointestinal disturbances such as diarrhea, nausea, and vomiting may commonly occur, and these symptoms usually improve naturally over time. Lactic acidosis is a very rare side effect but can be fatal; thus, if symptoms such as muscle pain, weakness, or difficulty breathing occur, immediate medical attention should be sought. This medication can interact with other drugs, so it is essential to inform the doctor or pharmacist of any other medications you are taking. Regular monitoring of blood sugar control is necessary, and there is a risk of vitamin B12 deficiency, so blood tests may be needed for monitoring. In case of overdose, there is a risk of hypoglycemia or lactic acidosis; therefore, it is important to adhere to the prescribed dosage and visit a medical facility immediately if any abnormal symptoms arise. Caution is required when driving or operating machinery, as symptoms of hypoglycemia or dizziness may occur. The safety and efficacy of this medication in children have not been sufficiently established; therefore, special caution is needed when administering it to pediatric patients.

Serious side effects

• Rash
• Severe swelling (edema)
• Chest tightness
• Difficulty breathing
• Severe thrombocytopenia accompanied by thrombocytopenic purpura
• Liver abnormalities (jaundice): yellowing of the skin or eyes, extreme fatigue
• Severe lactic acidosis
• Severe hypoglycemia
• Severe allergic reactions: difficulty breathing, hypotension, shock
• Cardiovascular issues: cardiac arrest

Mild side effects

• Gastrointestinal symptoms: diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain
• Specific sensory: unpleasant or metallic taste, transient visual impairment, taste disturbance
• Skin reactions: erythema, itching, rash
• Hematological abnormalities: thrombocytopenia, leukopenia, hemolytic anemia, erythropenia, agranulocytosis, pancytopenia
• Reduced and deficient vitamin B12
• Increased liver enzymes, liver dysfunction, hepatitis
• Allergic reactions

This medication should be stored in a tightly closed container to prevent air or moisture exposure. It is best to keep it at room temperature between 1 and 30 degrees Celsius.

Appearance

White oblong film-coated tablets

Package unit

30 tablets (10 tablets/PTP x 3)