Medirol M Tablets 2/500 Milligrams (Glimepiride, Metformin Hydrochloride)

Adult dose

This medication is administered 1-2 times daily just before or with meals. Treatment should begin with a low dose, and the dosage may be adjusted based on the patient's current medications and blood sugar levels. In clinical trials, the initial daily dose was glimepiride/metformin hydrochloride 2mg/500mg, and based on blood glucose monitoring results, the dosage was gradually increased up to glimepiride/metformin hydrochloride 8mg/2000mg.

This medication may cause severe lactic acidosis or hypoglycemia, so caution is needed. Particularly, if kidney function declines rapidly, metformin may accumulate in the body, increasing the risk of lactic acidosis. It is advisable to temporarily suspend medication and consult with a doctor if symptoms of dehydration occur. Care should also be taken when administered with other medications that can affect kidney function. Excessive alcohol intake, liver dysfunction, poorly controlled diabetes, prolonged fasting, and other factors can also pose risks. This medication should not be administered to patients with insulin-dependent diabetes or acute metabolic acidosis. Pregnant or breastfeeding women should also avoid use, and it is not administered to those with severe liver or kidney dysfunction. During the initial use of the medication, there is a high risk of hypoglycemia, so meals should be scheduled regularly and monitored carefully. Gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.) may occur, and these symptoms are usually temporary. If allergic reactions occur, the physician should be notified immediately, and rare blood disorders or vitamin B12 deficiency can also occur, necessitating regular check-ups. Blood sugar control status should be regularly monitored, and excessive alcohol consumption should be avoided during medication use. Furthermore, there may be interactions with other medications, so all medications currently being taken should be disclosed to healthcare professionals. In case of overdose, hypoglycemia or lactic acidosis may occur, requiring immediate medical assistance. The elderly may need dosage adjustments and regular renal function tests due to decreased kidney function. This medication has not established safety and efficacy for children, so caution is recommended, and one should be careful when driving or operating machinery due to potential hypoglycemia or impaired agility.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, dehydration due to diarrhea and vomiting, severe allergic reactions, severe rash with fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, liver abnormalities (jaundice), liver function impairment, hepatitis, liver failure, severe edema, increased blood pressure, heart-related abnormalities (cardiac arrest, cardiovascular collapse, acute myocardial infarction, congestive heart failure), difficulty breathing, asthma attacks, respiratory

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal bloating
• loss of appetite
• dyspepsia
• constipation
• abdominal pain
• fullness in the upper abdomen
• pressure sensation

This medication should be stored in a tightly sealed container to avoid exposure to air, and it is best kept at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness.

Appearance

White oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle