Dipyrilem Tablet 2/500 mg

Adult dose

This medication is administered 1 to 2 times a day just before or with meals. Dosages may be adjusted based on each patient's current therapy, efficacy, and tolerance, requiring proper blood sugar monitoring. Generally, treatment is started at low doses and the dosage can be adjusted based on the patient's current medications and blood sugar levels. In clinical trials, the initial daily dose was Glimepiride/Metformin Hydrochloride

This medication can cause severe lactic acidosis or hypoglycemia; therefore, if there is a rapid deterioration in kidney function or signs of dehydration, usage should be temporarily suspended, and a doctor should be consulted. Additionally, there may be an increased risk of cardiovascular disease, so attention to heart health is necessary while taking this medication. Patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver or kidney impairment, and women who are pregnant or breastfeeding should not take this medication. Particular attention is needed for the elderly, malnourished individuals, those with irregular eating habits, and excessive alcohol consumption regarding the risk of hypoglycemia, and immediate action should be taken if hypoglycemic symptoms occur. Initially, gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.) may appear, but these are generally temporary and can be alleviated by taking the medication with meals. This medication may decrease vitamin B12 levels; therefore, regular monitoring of vitamin B12 concentration is advisable during long-term use. Drug interactions may occur, so if there are other medications being taken, it is essential to inform the doctor or pharmacist. Women who are pregnant or planning to become pregnant should receive insulin therapy instead of this medication for safety. In case of overdose, hypoglycemia and lactic acidosis may occur; hence, do not change or discontinue your dosage without a doctor's advice and consult medical personnel immediately if any unusual symptoms appear. Be cautious of potential accidents due to hypoglycemia or reduced agility when driving or operating machinery. Keep out of the reach of children and do not transfer to other containers.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, chest tightness, severe allergic reactions, severe dermatological reactions (severe rash, blisters, skin peeling with fever, pain in oral/ocular mucosa), liver abnormalities (jaundice) and liver function impairment, sudden and severe headaches, confusion, visual disturbances, paralysis, serious neurological symptoms, marked decrease in urine output, severe generalized edema, edema accompanied by high blood pressure, lactic acidosis.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, dyspepsia, constipation, abdominal pain), metallic taste, visual impairment, taste disturbance, erythema, itching, rash, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, decreased vitamin B12 and deficiency, increased liver enzymes, hepatitis, allergic vasculitis, photosensitivity of the skin, decreased serum sodium concentration, and thyroid

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, ideally at room temperature between 1°C and 30°C. Proper storage helps maintain the effectiveness of the medication and prevents deterioration.

Appearance

White rectangular film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle