Aromil M Tablet 2/500 milligrams

Adult dose

This medication is administered 1 to 2 times daily before or with meals. The dosage may be adjusted based on each patient's current treatment regimen, efficacy, and tolerability, with appropriate blood sugar monitoring being necessary. Treatment typically starts at a low dose, with adjustments based on the patient's currently taken medications and blood sugar levels. In clinical trials, the initial daily dose was 2 mg of glimiperide/metformin hydrochloride.

This medication carries a risk of severe lactic acidosis or hypoglycemia; hence, it should be temporarily discontinued if renal function rapidly declines or in cases of dehydration. Patients with renal function below 45 mL/min/1.73 m² should not use this medication, and particular caution is advised for the elderly or those taking medications that may affect renal function. This medication may be associated with an increased risk of cardiovascular mortality; therefore, it is crucial to explain this clearly to patients before and during therapy and to monitor them accordingly. Do not administer to patients with insulin-dependent diabetes, severe liver impairment, pregnant or nursing women, or those with severe renal impairment. Patients at high risk for hypoglycemia, those with poor nutritional status or irregular eating patterns, individuals engaging in strenuous exercise, and those who consume alcohol excessively require close monitoring during treatment. Gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.) may commonly occur but are usually transient; consult a doctor if symptoms are severe. Allergic reactions or blood abnormalities may occur, so patients should immediately inform healthcare providers of symptoms such as hives, difficulty breathing, or bleeding. This medication can lower vitamin B12 levels, so regular checks of vitamin B12 levels are recommended during prolonged use. While taking this medication, regular checks of blood sugar, renal function, and blood tests should be performed, and immediate medical attention should be sought in cases of overdose due to risks of hypoglycemia or lactic acidosis. Moreover, avoid excessive alcohol intake, and inform healthcare providers prior to surgery or radiological examinations, as this may require temporary discontinuation of the medication. Caution is advised when driving or operating machinery due to potential decreased attention resulting from hypoglycemia or hyperglycemia. Particular care is needed for children and the elderly, and it is recommended that pregnant or nursing women avoid this medication.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, peeling skin, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), severe lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination changes.

Mild side effects

Diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain, temporary visual impairment due to changes in blood sugar levels, metallic taste, taste disorders, erythema, itching, rash, nausea, vomiting, fullness or pressure in the upper abdomen, abdominal pain, diarrhea, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, decreased/deficiency of vitamin B12, elevated liver enzymes, hepatic dysfunction.

This medication should be stored in a tightly closed container to prevent air ingress, ideally at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain its effectiveness for a longer period.

Appearance

White oblong film-coated tablet

Package unit

30 tablets/bottle