Glubiem Tablet 2/500 mg

Adult dose

This medication is administered 1 to 2 times daily just before meals or with meals. Treatment typically starts at a low dose and can be gradually increased based on blood glucose monitoring results. In clinical trials, the initial daily dosage was glymepiride/metformin hydrochloride 2mg/500mg, with experiences up to a maximum of 8mg/2000mg administered. Single-agent glymepiride generally does not provide additional effects when taken at doses above 4mg per day.

This medication can cause severe lactic acidosis or hypoglycemia; therefore, if there is a sudden decrease in kidney function or signs of dehydration, it is necessary to temporarily discontinue use and consult a physician. It is not to be administered to patients with renal function less than 45 mL/min/1.73m2, severe hepatic impairment, pregnant or breastfeeding women. During the initial dosing period, the risk of hypoglycemia is increased, so careful monitoring of blood glucose changes is particularly necessary for patients in poor nutritional status or irregular eating patterns, elderly patients, and those consuming alcohol. While taking this medication, gastrointestinal disturbances (such as diarrhea, nausea, vomiting) may occur, which are usually temporary; however, if symptoms are severe, a physician should be consulted. If allergic reactions or symptoms of skin rash, hematological abnormalities occur, notify a physician immediately, as severe symptoms may require emergency treatment. Regularly check blood sugar control status, and if symptoms of hypoglycemia occur, immediately consume sugar to regain control. This medication can interact with various drugs; thus, it is essential to inform healthcare providers if you are taking other medications or starting new ones. In cases of acute infection, pre- and post-surgery, dehydration, severe trauma, etc., it may be necessary to temporarily discontinue this medication. During pregnancy or if planning to become pregnant, insulin therapy is recommended instead of this medication. It should be used cautiously in children and the elderly, with regular kidney function tests conducted to ensure there are no abnormalities. Overdosage can lead to hypoglycemia or lactic acidosis, so strictly adhere to the prescribed dosage, and seek immediate assistance from healthcare providers if abnormal symptoms arise.

Serious side effects

• Hives, severe swelling.
• Severe allergic reactions.
• Difficulty breathing, respiratory distress.
• Respiratory issues.
• Yellowing of the skin or eyes (jaundice).
• Liver abnormalities.
• Sudden and severe headaches, seizures, confusion, visual disturbances, paralysis.
• Severe neurological symptoms.
• Significant decrease in urine output, severe generalized swelling, elevated blood pressure.
• Severe edema or urinary issues.

Mild side effects

• Gastrointestinal symptoms: diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain, feelings of fullness or pressure in the upper abdomen.
• Sensory issues: metallic taste, visual impairment, taste disorders.
• Skin reactions: erythema, itching, rash.
• Hematological abnormalities: thrombocytopenia, leukopenia, hemolytic anemia, anemia, agranulocytosis, pancytopenia.
• Decrease in vitamin B12 and peripheral neuropathy.
• Liver abnormalities: hepatic enzymes.

This medication should be stored in a sealed container to prevent air exposure, and it is best to keep it at room temperature between 1 to 30 degrees Celsius. This method of storage will help maintain the medication's effectiveness for a longer period.

Appearance

White oblong film-coated tablets

Package unit

30 tablets/bottle