Amaria M Tablets 2/500 mg

Adult dose

This medication is administered 1 to 2 times a day before meals or with meals. Dosages may be adjusted according to each patient's current treatment regimen, efficacy, and tolerability, and appropriate blood glucose monitoring should be conducted for this purpose. Typically, treatment is initiated at a low dose, and the dosage can be adjusted based on currently prescribed medications and blood glucose levels. The initial dose was glimepiride/metformin hydrochloride 2 mg/500 mg.

This medication may cause severe lactic acidosis or hypoglycemia; therefore, if there is a rapid decline in kidney function or signs of dehydration, it should be temporarily discontinued and a doctor should be consulted. Additionally, it should not be administered to patients with poor kidney function, those with severe liver impairment, pregnant or breastfeeding women, and patients with certain blood disorders. During treatment with this medication, there is a risk of hypoglycemia, so especially elderly patients, those with irregular eating patterns, and those who consume large amounts of alcohol should be closely monitored. Gastrointestinal symptoms such as diarrhea, nausea, and vomiting may occur, and if these symptoms are severe, caution is needed as they can lead to dehydration. As this medication is a blood sugar regulatory agent, it may interact with other medications, so it is essential to inform the doctor or pharmacist about any other medications taken. In patients with reduced kidney function, there is an increased risk of lactic acidosis due to the accumulation of this medication, so regular kidney function tests are necessary. Pregnant women or those planning to become pregnant are advised to replace this medication with insulin therapy. In cases of overdose, severe hypoglycemia or lactic acidosis may occur, so contact a medical facility immediately for appropriate treatment. Caution is needed when driving or operating machinery as hypoglycemia or agility impairment may occur. Regular monitoring of blood sugar, kidney function, and hematological tests is essential to verify safety and efficacy during treatment with this medication. Particularly in the elderly, reduced kidney function is common, so it is important to adjust the dosage and frequently check kidney function. Alcohol consumption may increase the risk of side effects from this medication, so caution is advised to avoid excessive drinking during treatment.

Serious side effects

• Urticaria
• Severe swelling (edema)
• Chest tightness
• Breathing difficulty
• Hypoglycemia
• Lactic acidosis
• Severe rash with fever, blisters, skin peeling, pain in oral or ocular mucosa
• Severe cutaneous adverse reactions
• Respiratory issues: Asthma attack, cough with fever accompanying breathing difficulty
• Yellowing of skin or eyes (jaundice)

Mild side effects

• Gastrointestinal symptoms: Diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain, upper abdominal fullness, pressure sensation.
• Specific sensory disturbances: Unpleasant metallic taste, vision impairment, taste disorders.
• Skin reactions and hypersensitivity: Erythema, itching, rash.
• Hematological abnormalities: Thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, neutropenia, agranulocytosis, pancytopenia.
• Vitamin B12 depletion and deficiency, macrocytic anemia.

This medication should be stored in a tightly sealed container that is well-ventilated, at a temperature between 1 degree and 30 degrees Celsius. This will help maintain the medication's efficacy for a prolonged period.

Appearance

White film-coated rectangular tablets

Package unit

For domestic use - 30 tablets/bottle, For domestic use - 100 tablets/bottle