Paramet Tablet (Rabeprazole Sodium)

Adult dose

For gastric ulcers and duodenal ulcers: Generally, 10 mg is taken orally once a day. Depending on symptoms, 20 mg can be taken orally once a day. The treatment can extend to 8 weeks for gastric ulcers and to 6 weeks for duodenal ulcers. For erosive or ulcerative gastroesophageal reflux disease: 10 mg or 20 mg is taken once a day for 4 to 8 weeks. If symptoms persist, an additional 8 weeks of 10 mg or 20 mg can be administered twice a day.

This drug should not be used in patients with hypersensitivity to this drug, its ingredients, or benzimidazole derivatives. Patients who are allergic to penicillin antibiotics should be cautious when using this drug with amoxicillin during the eradication of Helicobacter pylori. Patients with hypersensitivity to macrolide antibiotics should also be cautious when using this drug with clarithromycin. Patients taking certain heart-related medications, such as terfenadine, cisapride, pimozide, or astemizole, should not use this drug in combination. Patients who are taking atazanavir or rilpivirine should avoid using this drug. Pregnant or breastfeeding women should not take this drug, as its safety has not been confirmed. Patients with decreased liver function, elderly individuals, and those with a history of hypersensitivity to medications should be cautious when using this drug. If allergic reactions such as rash, hives, or itching occur during treatment, therapy should be discontinued immediately. Regular blood tests are needed as the drug may cause abnormalities in red blood cell or white blood cell counts. Liver function tests should also be performed regularly, and the drug should be discontinued if symptoms of hepatitis or jaundice arise. Cardiovascular issues, such as hypertension, myocardial infarction, or ECG abnormalities, may rarely occur, thus requiring caution. Gastrointestinal symptoms can include diarrhea, constipation, abdominal pain, or nausea, so any abnormal symptoms should be reported. Neurological symptoms may include headaches, insomnia, dizziness, or anxiety, necessitating caution. Respiratory symptoms such as cough, pharyngitis, or dyspnea may arise. Musculoskeletal symptoms such as myalgia or arthralgia may occur rarely. Skin reactions such as rash, itching, or hair loss may appear, and severe skin reactions necessitate immediate discontinuation of the drug. Special sensory abnormalities such as visual disturbances, tinnitus, or eye pain have also been reported, and consultation with a physician is advised if symptoms occur. Urinary tract issues, such as proteinuria, cystitis, or hematuria, may arise. This drug has been associated with an increased risk of bone fractures with long-term use, so caution is necessary. Additionally, prolonged usage may lead to hypomagnesemia, thus regular blood tests are recommended. As this drug suppresses gastric acid secretion, the risk of bacterial infection in the gastrointestinal tract may slightly increase, hence medical attention should be sought if diarrhea persists. Caution is advised when driving or operating machinery as drowsiness may occur. When used with other medications, potential interactions may arise, so inform healthcare providers about all medications being taken. Particularly, when using with warfarin, methotrexate, or antibiotics, follow professional advice. This drug should be swallowed whole in tablet form without chewing or crushing, and kept out of the reach of children. In case of overdose, since there is no specific antidote, symptomatic treatment is vital. It is safe to undergo regular examinations and monitoring during the course of taking this medication as directed by a physician.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, fever, severe allergic reactions, severe skin reactions, jaundice, liver abnormalities, sudden and very severe headaches, seizures, confusion, visual disturbances, paralysis, severe neurological symptoms, drastic reduction in urine output, generalized severe swelling, elevated blood pressure, severe swelling or urinary abnormalities, acute hepatic failure, liver dysfunction, toxic epidermal necrolysis (Stevens-Johnson syndrome), mucosal skin reactions.

Mild side effects

• Rash
• itching
• decreased red blood cell count
• decreased white blood cell count
• increased white blood cell count
• increased eosinophils
• increased neutrophils
• decreased lymphocytes
• anemia
• petechiae

This drug is susceptible to air and humidity, so it must be stored in a tightly sealed container. It is best to maintain a storage temperature between 1°C and 30°C at room temperature. This way, the efficacy of the drug is preserved, and use can be safe.

Appearance

Pale yellow round enteric-coated tablet

Package unit

28 tablets (14 tablets/PTP X 2)