Diphon Tablets (Thienorphine Sodium)

Adult dose

○ Adults : Administer tianeptine sodium 12.5 mg orally 3 times daily before meals. ○ Limit administration to 2 times daily in elderly patients aged 70 years or older or patients with renal impairment. ○ Adjust the dose as appropriate according to symptoms. ○ Avoid abrupt discontinuation of treatment. To reduce the risk of withdrawal reactions, gradually taper the dose over 7 ~ 14 days. (See “General precautions” under Precautions for use.)

This medicine is used in the treatment of depression and may increase the risk of suicidal thoughts or self-harm, so the patient's condition must be closely monitored for several weeks after starting treatment. Especially, patients with a history of suicide attempts or suicidal thoughts require more careful management throughout the treatment period. This medicine should not be administered to children under 15 years of age, patients with certain rare genetic disorders, and patients taking MAO inhibitors. Patients who have an allergic reaction to this medicine should also not use it. Various side effects such as decreased appetite, nightmares, insomnia, drowsiness, headaches, palpitations, and gastrointestinal discomfort may occur during use; if symptoms are severe, consult a doctor. Before undergoing surgery, inform the anesthesiologist that you are taking this medicine and, if necessary, discontinue use 24-48 hours before surgery. It is advisable not to take this medicine together with alcohol or medications containing alcohol. If discontinued abruptly, withdrawal symptoms such as anxiety, muscle pain, and insomnia may occur, so the dosage should be gradually reduced according to the doctor's direction. Caution is needed as drowsiness may occur when driving or operating machinery. Patients with impaired renal function or the elderly may experience prolonged half-life of the drug; thus, taking it twice a day is recommended. In case of overdose, symptoms such as drowsiness or coma may occur, so immediate medical attention is necessary. Store in a safe place out of reach of children and do not transfer to another container.

• Loss of appetite
• hyponatremia
• nightmares
• drug abuse and dependence
• suicidal thoughts
• suicidal behavior
• confusion
• hallucinations
• insomnia
• drowsiness

This medicine may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained at room temperature between 1 and 30 degrees Celsius to safely preserve the effectiveness of the medicine.

Appearance

White oval film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle